The study was aimed to observe the morphology of intraepidermal nerve fibre (IENF) and to explore the relationships between intraepidermal nerve fibre density (IENFD) and anatomic sites, age, genders and races. Intraepidermal nerve fibre was observed using immunohistochemistry. The relationships between IENFD and anatomic sites, ages, genders and races were analysed by quantitative analysis of IENFD. Five patterns of the IENFs were observed according to the morphological classification. A significant difference was observed in IENFD between different anatomic sites (P < 0.05). A linear negative correlation was observed between IENFD and age (r = - 0.2931, P < 0.01). No significant difference was found between IENFD and genders. Intraepidermal nerve fibre density at distal leg of Chinese (395.54 ± 166.92) was higher than that of Finnish (114.62 ± 32.32, P < 0.01). Skin biopsy may be an effective tool in quantitation of IENFD in healthy individuals. Intraepidermal nerve fibre density is independent of genders, and closely associated with anatomic sites, races and ages.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1179/1743132815Y.0000000082 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Evidence for spinal disinhibition as a pain-generating mechanism in fibromyalgia syndrome.
Pain Rep
February 2025
Pain Research Institute, Institute of Life Course and Medical Sciences, University of Liverpool, Liverpool, United Kingdom.
Introduction: Pain phenomenology in patients with fibromyalgia syndrome (FMS) shows considerable overlap with neuropathic pain. Altered neural processing leading to symptoms of neuropathic pain can occur at the level of the spinal cord, and 1 potential mechanism is spinal disinhibition. A biomarker of spinal disinhibition is impaired H-reflex rate-dependent depression (HRDD).
View Article and Find Full Text PDFEffect of Advillin Knockout on Diabetic Neuropathy Induced by Multiple Low Doses of Streptozotocin.
J Physiol Investig
December 2024
Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.
Advillin is an actin-binding protein involved in regulating the organization of actin filaments and the dynamics of axonal growth cones. In mice, advillin is exclusively expressed in somatosensory neurons, ubiquitously expressed in all neuron subtypes during neonatal ages and particularly enriched in isolectin B4-positive (IB4+) non-peptidergic neurons in adulthood. We previously showed that advillin plays a key role in axon regeneration of somatosensory neurons during peripheral neuropathy.
View Article and Find Full Text PDFMitochondrial A adenosine receptor as a mechanism for the protective effects of AAR agonists on chemotherapy-induced neuropathic pain.
J Neurosci
December 2024
Department of Pharmacology and Physiology, Saint Louis University School of Medicine, 1402 South Grand Boulevard, Saint Louis, MO 63104.
Alterations in mitochondrial function are the linchpin in numerous disease states including in the development of chemotherapy-induced neuropathic pain (CIPN), a major dose-limiting toxicity of widely used chemotherapeutic cytotoxins. In CIPN, mitochondrial dysfunction is characterized by deficits in mitochondrial bioenergetics (e.g.
View Article and Find Full Text PDFLevodopa Impairs Lysosomal Function in Sensory Neurons In Vitro.
Biology (Basel)
November 2024
Department of Pharmacology, Institute of Biomedicine and Translational Medicine, University of Tartu, 50411 Tartu, Estonia.
Parkinson's disease (PD) is the second-most common neurodegenerative disease worldwide. Patients are diagnosed based upon movement disorders, including bradykinesia, tremor and stiffness of movement. However, non-motor signs, including constipation, rapid eye movement sleep behavior disorder, smell deficits and pain are well recognized.
View Article and Find Full Text PDFCutaneous Carbonyl Stress Is Associated With Nerve Dysfunction in Recent-Onset Type 2 Diabetes.
Diabetes Care
November 2024
Institute for Clinical Diabetology, German Diabetes Center, Leibniz Center for Diabetes Research at Heinrich-Heine-University Düsseldorf, Düsseldorf, Germany.
Objective: Endogenous carbonyl stress leads to the formation of advanced glycation end products (AGEs). AGEs represent a potential target to prevent or treat diabetic sensorimotor polyneuropathy (DSPN). The current study aimed to characterize cutaneous carbonyl stress, oxidative stress, immune cells, and endothelial cell damage in early type 2 diabetes compared with normal glucose tolerance (NGT) using novel cutaneous biomarkers.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!