AI Article Synopsis
- Various imaging methods exist for diagnosing and assessing renal cell carcinoma (RCC), with contrast enhanced CT being the standard for size and shape evaluation.
- Perfusion CT (pCT) offers a functional imaging approach that dives deeper into the molecular aspects, revealing information about tumor blood flow and permeability, which are important for understanding tumor behavior.
- pCT can detect changes in tumor response sooner than traditional size measurements, helping to improve prognosis, therapy selection, and evaluation of treatment effectiveness in RCC patients.
Article Abstract
Various imaging modalities are available for the diagnosis, staging and response evaluation of patients with renal cell carcinoma (RCC). While contrast enhanced computed tomography (CT) is used as the standard of imaging for size, morphological evaluation and response assessment in RCC, a new functional imaging technique like perfusion CT (pCT), goes down to the molecular level and provides new perspectives in imaging of RCC. pCT depicts regional tumor perfusion and vascular permeability which are indirect parameters of tumor angiogenesis and thereby provides vital information regarding tumor microenvironment. Also response evaluation using pCT may predate the size criteria used in Response Evaluation Criteria in Solid Tumors, as changes in the perfusion occurs earlier following tissue kinase inhibitors before any actual change in size. This may potentially help in predicting prognosis, better selection of therapy and more accurate and better response evaluation in patients with RCC. This article describes the techniques and role of pCT in staging and response assessment in patients with RCCs.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4506935 | PMC |
| http://dx.doi.org/10.4329/wjr.v7.i7.170 | DOI Listing |
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