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Association between IV and topical tranexamic acid use and periprosthetic joint infections in hip and knee arthroplasty: a retrospective study.
BMC Musculoskelet Disord
December 2024
Department of Orthopaedic Surgery, Kaohsiung Chang Gung Memorial Hospital, No. 123, Dapi Road, Niaosong District, Kaohsiung, 833, Taiwan.
Article Synopsis
- Anemia and blood transfusions increase the risk of periprosthetic joint infections (PJI), and tranexamic acid (TXA) is known to reduce surgery-related blood loss and transfusions.
- A retrospective study involving over 8,000 patients examined the effects of TXA on PJI rates following total joint arthroplasty (TJA), comparing those who received TXA (either intravenous or topical) to those who did not.
- Results indicated that TXA significantly reduced PJI occurrences (1.1% vs. 2.1%), decreased blood transfusion rates, and led to shorter hospital stays, with no significant differences in venous thromboembolism or readmission rates.
Subcutaneous and Topical Tranexamic Acid Use During Rhytidectomy.
Laryngoscope
December 2024
Robertson Cosmetic Clinic, Middleton, Wisconsin, U.S.A.
Objective: Tranexamic acid is a potential rhytidectomy adjunct; however, its route of administration, benefits, and safety remain a topic of debate. The purpose of this study is to analyze the effects of topical and subcutaneous TXA during rhytidectomy.
Methods: This is a retrospective, 3-arm analysis of a single surgeon's practice from Aug.
Postpartum Hemorrhage in Humanitarian Settings: Heat-Stable Carbetocin and Tranexamic Acid Implementation Study in Uganda.
Int J MCH AIDS
September 2024
United Nations Population Fund, Humanitarian Response Division, Switzerland.
Article Synopsis
- - The study investigates the effectiveness of a capacity-strengthening package to promote the use of heat-stable carbetocin (HSC) and tranexamic acid (TXA) in preventing and treating postpartum hemorrhage (PPH) in basic obstetric clinics in Uganda during crisis situations.
- - A total of 2,299 women participated over a year, showing that while the use of prophylactic uterotonics was high, the introduction of HSC contributed to changes in the overall treatment practices, with a notable increase in TXA usage.
- - The results highlight that enhancing healthcare provider capabilities can lead to improved management of PPH, suggesting critical implications for global health strategies in humanitarian settings.
Postpartum Hemorrhage in Humanitarian Settings: Heat-Stable Carbetocin and Tranexamic Acid Implementation Study in South Sudan.
Int J MCH AIDS
September 2024
United Nations Population Fund, Humanitarian Response Division, Switzerland.
Article Synopsis
- The study assesses the impact of a capacity-strengthening package on the use of medications for preventing and treating postpartum hemorrhage (PPH) in South Sudan's basic maternity facilities.
- The implementation involved a series of phases introducing therapeutic protocols, including training and resources, resulting in improved use of uterotonics and a notable increase in PPH diagnoses.
- Findings indicate a transition in medication usage patterns, with oxytocin usage decreasing as heat-stable carbetocin and tranexamic acid were introduced, highlighting the need for effective PPH management strategies in crisis-affected areas.
Does tranexamic acid reduce blood loss for children undergoing reconstruction for neuromuscular hip dysplasia? A matched comparative study.
J Pediatr Orthop B
November 2024
Department of Biostatistics, Center for Biostatistics and Data Science, Washington University School of Medicine, St. Louis, Missouri, USA.
Treatment for neuromuscular hip dysplasia (NMHD) typically involves osteotomies of the proximal femur and/or pelvis, and the potential for significant volume blood loss is high. Tranexamic acid (TXA) functions as an antifibinolytic and has been shown to reduce bleeding in many operative settings. Retrospective evidence for the use of TXA in children undergoing NMHD reconstruction is inconclusive, and to our knowledge, prospective evaluation has never been performed.
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