Objective: To study the correlation on chemical fingerprint features between Trichosanthis Fructus and its processed products.
Methods: The chemical fingerprints were established by HPLC for the ethyl acetate extraction and the n-butanol extraction in Trichosanthis Fructus and its processed products,the common pattern was established by the mean and the median, and the similarity degree between Trichosanthis Fructus and its processed products was calculated by the correlation coefficient method and the included angle cosine method.
Results: There were 24 common peaks in the fingerprints of ethyl acetate extraction of Trichosanthis Fructus and its processed products,the average similarity degree was calculated separately by the correlation coefficient method and the included angle cosine method:the former as the value was 0. 8497(mean), 0. 8344(median); and the latter as the value was 0. 8429(mean), 0. 8536 (median); there were 6 common peaks in the fingeprints of n-butanol extraction of Trichosanthis Fructus and its processed products, the average similarity degree was calculated by the correlation coefficient method and the included angle cosine method:the former as the value was 0. 9044 (mean), 0. 9076 (median); and the latter as the value was 0. 9075 (mean), 0. 9081 (median).
Conclusion: Main peaks have good correlation between Trichosanthis Fructus and its processed products. This method can provide theoretical basis for processing and quality control of Trichosanthis Fructus.
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