AI Article Synopsis
- Aeschynomene fascicularis, a plant used in Mayan medicine, has not been thoroughly studied for its medicinal compounds.
- The root bark of the plant was extracted with methanol, and various fractions were created for testing their effects on cancer cells.
- Compounds isolated from these extracts, particularly spinochalcone A, secundiflorol G, and isocordoin, showed significant cytotoxic and antiproliferative effects against multiple cancer cell lines, indicating their potential as cancer treatments.
Article Abstract
The plant Aeschynomene fascicularis (Fabaceae) has been used in Mayan traditional medicine in the Yucatan peninsula. However, the compounds present in the plant responsible for its curative properties have not yet been investigated. Aeschynomene fascicularis root bark was extracted with 100% methanol to obtain a crude extract. The methanol extract was partitioned successively with solvents with increasing polarity to obtain the corresponding hexane (Hx), dichloromethane (DCM) and ethyl acetate fractions (EtOAc), as well as a residual water-alcoholic fraction. These fractions were tested for their cytotoxic activities using an MTT assay against Hep-2 cancer cell lines. The Hx fraction led to the isolation of spinochalcone C (1), spinochalcone A (2), isocordoin (3) and secundiflorol G (4). Their structures were identified based on spectroscopic evidence and chemical properties. All compounds were subjected to cytotoxicity and antiproliferative assays against a panel of seven cell lines, including one normal-type cell line. Spinochalcone A (2) exhibited cytotoxic activity against DU-145 cell line and antiproliferative activity against the KB cell line. Secundiflorol G (4) showed strong cytotoxic activity towards KB and Hep-2 cell lines. In addition, isocordoin (3) showed moderate activity on KB, Hep-2 and DU-145 cell lines. The active Compounds 2, 3 and 4 are potential therapeutic entities against cancer.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6332200 | PMC |
| http://dx.doi.org/10.3390/molecules200813563 | DOI Listing |
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