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Distinct phenotypes in a cohort of anti-CASPR2 associated neurological syndromes.
Clin Neurol Neurosurg
November 2023
Department of Neurology, Centro Hospitalar Universitário do Porto, Porto, Portugal; Unit for Multidisciplinary Research in Biomedicine (UMIB), Instituto de Ciencias Biomedicas de Abel Salazar, Universidade do Porto, Porto, Portugal; Clinical Immunology Unit, Centro Hospitalar Universitário do Porto, Porto, Portugal.
Introduction: Anti-contactin-associated protein-like 2 (CASPR2) is classically associated with limbic encephalitis (LE), Morvan syndrome and peripheral nerve hyperexcitability (PNH). Additional clinical features have been previously recognized.
Objective: To describe a cohort of patients with anti-CASPR2-associated neurological syndromes from a tertiary referral centre.
Isolated Adie Pupil Associated With Anti-CASPR2 Antibodies.
J Neuroophthalmol
December 2023
Department of Neurology (JM, ES), Centro Hospitalar Universitário do Porto, Porto, Portugal; Immunology Department (PC, EN), Centro Hospitalar Universitário do Porto, Porto, Portugal; Unit for Multidisciplinary Research in Biomedicine (UMIB) (PC, EN, ES), Instituto de Ciencias Biomedicas de Abel Salazar, Universidade do Porto, Porto, Portugal; and Clinical Immunology Unit (ES), Centro Hospitalar Universitário do Porto, Porto, Portugal.
Acute Oropharyngeal Palsy Following Bilateral Adie's Tonic Pupils Associated with Anti-GT1a and GQ1b IgG Antibodies.
Intern Med
October 2022
Department of Neurology, Wakayama Medical University, Japan.
A 36-year-old man was admitted to our hospital with complaints of dysphagia and photophobia. A neurological examination showed oropharyngeal palsy and bilateral mydriasis with loss of light reflexes in the absence of external ophthalmoplegia. Bilateral pupils were supersensitive to pilocarpine 0.
View Article and Find Full Text PDFComputational 4D-OCM for label-free imaging of collective cell invasion and force-mediated deformations in collagen.
Sci Rep
February 2021
Nancy E. and Peter C. Meinig School of Biomedical Engineering, Cornell University, Ithaca, NY, 14853, USA.
Traction force microscopy (TFM) is an important family of techniques used to measure and study the role of cellular traction forces (CTFs) associated with many biological processes. However, current standard TFM methods rely on imaging techniques that do not provide the experimental capabilities necessary to study CTFs within 3D collective and dynamic systems embedded within optically scattering media. Traction force optical coherence microscopy (TF-OCM) was developed to address these needs, but has only been demonstrated for the study of isolated cells embedded within optically clear media.
View Article and Find Full Text PDFImplementing early mobilisation after knee or hip arthroplasty to reduce length of stay: a quality improvement study with embedded qualitative component.
BMC Musculoskelet Disord
November 2020
South West Clinical School UNSW, Locked bag 7103, Liverpool BC, NSW, Australia.
Background: Models of care for managing total knee or hip arthroplasty (TKA, THA) incorporating early mobilisation are associated with shorter acute length-of-stay (LOS). Few studies have examined the effect of implementing early mobilisation in isolation, however. This study aimed to determine if an accelerated mobilisation protocol implemented in isolation is associated with a reduced LOS without undermining care.
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