Background: Unattended home-based polysomnography (H-PSG) is a reliable tool for the diagnosis of obstructive sleep apnoea (OSA). The quality of the recording can be influenced by several factors including the set-up location - at home versus in the sleep laboratory. Previous studies have suggested that the failure rate is higher when H-PSG is fitted in hospital. The aim of this study was to determine the influence of hook-up location on H-PSG recording quality. Feasibility and repeatability of H-PSG were also assessed.
Methods: Consecutive patients suspected of OSA were selected. Each patient underwent two H-PSGs within two weeks, one fitted at home and one fitted in the sleep laboratory. The order of H-PSG was randomly assigned.
Results: Among the 102 included patients, 95 completed the study. Ninety-three per cent of the 190 H-PSGs were satisfactory. The failure rate of H-PSG was similar for both the home set-up and the sleep laboratory set-up (p = 0.33). Seventy-nine per cent of patients opted to be fitted at home. OSA was diagnosed in 59%. The apnoea-hypopnoea index was similar for home and sleep laboratory set-up, resulting in a very good reproducibility (intraclass correlation coefficient of 0.85). No differences in total sleep time and sleep architecture were observed in both set-up protocols. Except for sleep duration, which was longer in the first H-PSG test, we did not observe any first-night effect during the first H-PSG.
Conclusion: The present study demonstrates that hospital hook-up is as effective as home hook-up for home-unattended polysomnography, and that feasibility and repeatability of H-PSG are very good.
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http://dx.doi.org/10.1016/j.sleep.2015.04.006 | DOI Listing |
Alzheimers Dement
December 2024
Laboratory of Neuroscience (LIM-27), Department and Institute of Psychiatry, Faculty of Medicine, University of São Paulo, São Paulo, São Paulo, Brazil.
Background: Sleep-related breathing disorders are commonly reported in the Down Syndrome (DS) population, but data on its prevalence and severity are scarce, especially for the adult population. The increase in life expectancy and premature aging in patients with DS reinforces the need for an assessment of sleep quality. This study evaluated sleep-disordered breathing in adults with DS using sleep measures by polysomnography.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
Center for Alzheimer's Research and Treatment, Brigham and Women's Hospital/Harvard Medical School, Boston, MA, USA.
Background: Medical history and healthcare utilization in preclinical Alzheimer's disease (AD) are not well characterized and may reveal indicators associated with asymptomatic stages of AD.
Methods: This retrospective observational study compared 246 Anti-Amyloid Treatment in Asymptomatic AD study (A4) individuals who met elevated brain amyloid eligibility criteria to 121 individuals in the companion Longitudinal Evaluation of Amyloid Risk and Neurodegeneration study (LEARN) who were eligible for A4 except did not meet elevated amyloid eligibility criteria. Matched-controls for A4/LEARN, using a 3:1 match of demographics, Medicare enrollment month, and frailty status, were randomly selected from Medicare beneficiaries without cognitive impairment/dementia claims.
Alzheimers Dement
December 2024
North Bristol NHS Trust, Bristol, United Kingdom.
Background: Poor sleep is associated with neurodegenerative diseases underlying dementia and mild cognitive impairment (MCI), including Alzheimer's disease (AD) and Lewy body disease (LBD). Performing assessments within clinical or laboratory settings may influence validity, however feasibility of home sleep and memory assessments in this population is currently undetermined. This study aimed to identify whether remote home-based sleep and memory research including wearable technology was feasible in older adults with MCI and dementia.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
Michigan State University, East Lansing, MI, USA.
Background: Confabulation, the fabrication of details with short lucid intervals, hinders the diagnosis of Alzheimer's and other dementias. This case report explores the complexities of diagnosing and managing Alzheimer's dementia in a culturally diverse patient exhibiting fluctuating memory and confabulation, emphasizing challenges heightened by cultural and linguistic factors.
Case: An 84-year-old African descent man resided with his family in the United States, independent in his basic daily activities but struggling with instrumental tasks due to memory impairment.
Hum Brain Mapp
January 2025
Sleep and NeuroImaging Center, Faculty of Psychology, Southwest University, Chongqing, China.
Insomnia disorder (ID) is a highly heterogeneous psychiatric disease, and the use of neuroanatomical data to objectively define biological subtypes is essential. We aimed to examine the neuroanatomical subtypes of ID by morphometric similarity network (MSN) and the association between MSN changes and specific transcriptional expression patterns. We recruited 144 IDs and 124 healthy controls (HC).
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