AI Article Synopsis
- Cells can become less fit during their lifespan, which raises questions about how these damaged cells are managed in adult tissues.
- Using the Drosophila posterior midgut as a model, the study explores how competition among cells influences stem cell behavior and overall tissue health.
- Healthy cells can eliminate weaker cells, while also proliferating and self-renewing themselves, and this process is driven by signals from stress-responsive cells.
Article Abstract
Throughout their lifetime, cells may suffer insults that reduce their fitness and disrupt their function, and it is unclear how these potentially harmful cells are managed in adult tissues. We address this question using the adult Drosophila posterior midgut as a model of homeostatic tissue and ribosomal Minute mutations to reduce fitness in groups of cells. We take a quantitative approach combining lineage tracing and biophysical modeling and address how cell competition affects stem cell and tissue population dynamics. We show that healthy cells induce clonal extinction in weak tissues, targeting both stem and differentiated cells for elimination. We also find that competition induces stem cell proliferation and self-renewal in healthy tissue, promoting selective advantage and tissue colonization. Finally, we show that winner cell proliferation is fueled by the JAK-STAT ligand Unpaired-3, produced by Minute(-/+) cells in response to chronic JNK stress signaling.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4537514 | PMC |
| http://dx.doi.org/10.1016/j.devcel.2015.06.010 | DOI Listing |
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