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Hydroxyethylamine based analog targets microtubule assembly: an in silico study for anti-cancerous drug development.
Sci Rep
December 2024
Department of Biotechnology, Mahatma Gandhi Central University, Motihari, 845401, India.
Microtubules are dynamic cytoskeletal structures essential for cell architecture, cellular transport, cell motility, and cell division. Due to their dynamic nature, known as dynamic instability, microtubules can spontaneously switch between phases of growth and shortening. Disruptions in microtubule functions have been implicated in several diseases, including cancer, neurodegenerative disorders such as Alzheimer's and Parkinson's disease, and birth defects.
View Article and Find Full Text PDFA real-world disproportionality analysis of colchicine: data mining of the public version of FDA Adverse Event Reporting System.
Expert Opin Drug Saf
December 2024
Department of Cardiology, Intervention Cardiology Center, Wuhan No.1 Hospital, Wuhan, China.
Background: Colchicine is widely used for gout and familial Mediterranean fever (FMF) and has cardiovascular benefits. However, it is linked to various adverse drug reactions (ADRs). This study aimed to analyze colchicine-related ADRs using FAERS data for safer clinical use.
View Article and Find Full Text PDFHarnessing Nanotechnology for Gout Therapy: Colchicine-Loaded Nanoparticles Regulate Macrophage Polarization and Reduce Inflammation.
Biomater Res
December 2024
Department of The Fourth Otolaryngology Head and Neck Surgery, Shengjing Hospital of China Medical University, Shenyang 110000, China.
Gout is a disease caused by hyperuricemia, characterized by inflammation reactions triggered by macrophage polarization. Colchicine is a commonly used drug for gout treatment, but its mechanism of action remains unclear. The aim of this study was to investigate the regulatory effect of colchicine on macrophage polarization to enhance the therapeutic effectiveness against gout inflammation.
View Article and Find Full Text PDFGenome-wide association study of haploid female fertility (HFF) and haploid male fertility (HMF) in BS39-derived doubled haploid maize lines.
Theor Appl Genet
December 2024
Department of Agronomy, Iowa State University, Ames, IA, 50011, USA.
Restoration of haploid female and haploid male fertility without colchicine is feasible. Three SNPs and eight gene models for HFF, and one SNP and a gene model for HMF were identified. Doubled haploid (DH) breeding accelerates the development of elite inbred lines and facilitates the incorporation of exotic germplasm, offering a powerful tool for maize improvement.
View Article and Find Full Text PDFComprehensive multi-omics analysis elucidates colchicine-induced toxicity mechanisms and unveils the therapeutic potential of MLN4924 and kinase inhibitors.
Acta Pharmacol Sin
November 2024
Jiangsu Key Laboratory of Marine Pharmaceutical Compound Screening, College of Pharmacy, Jiangsu Ocean University, Lianyungang, 222005, China.
Colchicine is a widely prescribed anti-inflammatory drug for the treatment of gout, familial Mediterranean fever and pericarditis, but its narrow therapeutic window presents a significant risk of severe toxicity. Despite its clinical relevance, the molecular mechanisms underlying colchicine's pharmacological effects and associated toxicity and explored potential therapeutic interventions to mitigate its adverse effects. We showed the colchicine's impact on cellular morphology in human umbilical vein endothelial cells (HUVEC) and HeLa cells including cell rounding and detachment following 24 h of exposure that revealed pronounced cytotoxic effects.
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