Background: The objective of this study was to evaluate the time-related trends of tumor characteristics and postoperative survival of patients with gastric cancer (GC) in 2 high-volume centers in high incidence areas of southern China.
Methods: Based on the meticulously collected data from 5,327 patients with GC treated with operative intervention at Sun Yat-sen University Cancer Center and Fujian Medical University Union Hospital, we analyzed the differences in clinicopathologic features and postoperative survival over the following 4 consecutive periods: 1991-1995 (period 1), 1996-2000 (period 2), 2001-2005 (period 3), and 2006-2010 (period 4).
Results: Tumor size decreased (P = .001), but the proportion of poorly differentiated tumors increased (P < .001) over the study periods. Early GC was diagnosed more often in later periods, gradually increasing from 7 to 15% (P < .001). A surprising improvement was observed in the mean number of retrieved lymph nodes, ranging from 10.36 to 26.22 (P < .001). The radical resection rate increased from 88 to 93%. The overall 5-year survival rate improved steadily over the 4 periods, from 39 to 53% (P < .001). Multivariate analysis revealed that age, tumor location, histologic type, tumor size, depth of invasion, lymphatic invasion, number of retrieved lymph nodes, radical resection, and time periods were independent prognostic factors.
Conclusion: The clinicopathologic features of tumors changed during the observation period in our region. The increasingly early detection of patients with GC and more standardized regimens for operative management, including routinely performed D2 lymphadenectomy, most likely resulted in the increase in overall survival.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.surg.2015.04.038 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Characterization of different clinical presentation of Merkel cell carcinomas and their potential prognostic implications.
Clin Exp Dermatol
January 2025
Skin Cancer Center, Azienda Unità Sanitaria Locale - IRCCS di Reggio Emilia, Reggio Emilia, Italy.
Background: Recent studies analyzed the impact of Merkel cell polyomavirus (MCPyV) on the prognosis of Merkel cell carcinoma (MCC) patients. No data on specific morphological clinical differences of MCPyV+ or MCPyV- are currently available neither on the possible prognostic implication of different clinical presentation of MCC.
Objectives: 1) to describe clinicopathological characteristics of MCC patients and the prevalence of MCPyV infection in an Italian cohort of patients; 2) to define possible differences in clinicopathological and prognostic features among MCPyV+ and MCPyV- MCCs.
Clinicopathologic Characteristics of 40 Cases of Juvenile Conjunctival Nevus.
Am J Dermatopathol
January 2025
Center for Pathology Diagnosis, Xi 'an People's Hospital (Xi 'an Fourth Hospital), Xi 'an, Shaanxi, China.
Aims: Limited studies have been conducted on juvenile conjunctival nevus (JCN) in Asian populations. This study aims to investigate the clinical and pathologic characteristics of JCN cases among the Han ethnicity in northwest China, providing insights for pathologists and ophthalmologists in diagnosing this condition.
Methods: A subset of conjunctival nevi in children and adolescents, characterized by a confluent growth pattern and lack of maturation, was identified and defined as JCN.
EVALUATION AND MANAGEMENT OF PARATHYROID INCIDENTALOMAS DETECTED BY ROUTINE NECK ULTRASONOGRAPHY WITH A MULTIDISCIPLINARY CLINICAL APPROACH.
Acta Endocrinol (Buchar)
January 2025
University of Health Sciences, Gulhane Training and Research Hospital, Nuclear Medicine Department.
Contex: Detection of parathyroid incidentalomas (PTIs) by ultrasonography (US) generally depends on clinical experience and it can be usually confused with perithyroidal lymph nodes.
Objective: We aimed to evaluate the role of US for the detection of PTIs and define clinicopathologic features of PTIs detected during routine neck US.
Design: In this retrospective study, we studied PTIs in a multidisciplinary clinical approach of nuclear medicine and general surgery clinics.
Profiling of Oral Squamous Cell Carcinoma of Lower Assam Region - A Hospital-Based Retrospective Study.
Contemp Clin Dent
December 2024
Department of Dentistry, Assam Cancer Care Foundation, Barpeta, Assam, India.
Background: Oral cancer is one of the ten most common cancers worldwide and the sixth most common type of all cancer in India. Among the oral malignancies, oral squamous cell carcinoma (OSCC) is the most common, accounting for more than 90% of oral cancer and hence a significant public health concern.
Aim: The aim of this study was to evaluate clinicopathological and demographic profiling of OSCC in a district and adjacent area of lower Assam.
Proteasome inhibitors prevent tumor cell proliferation in HHV-8-unrelated PEL-like lymphoma.
Leuk Res Rep
December 2024
Tokyo Women's Medical University, Adachi Medical Center, Department of Medicine, 4-33-1 Kohoku Adachi-ku, Tokyo, Japan.
Primary effusion lymphoma (PEL)-like lymphoma is a rare variant of PEL that exhibits diverse clinical behaviors, ranging from mild to aggressive disease courses. The clinicopathological features and effective treatments for this type of lymphoma have not been well defined. We found that proteasome inhibitors were effective in inhibiting the growth and survival of OGU1 cells, which were derived from a patient with aggressive PEL-like lymphoma, highlighting the critical role of proteasome activity in the proliferation of PEL-like lymphoma cells.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!