AI Article Synopsis
- Diabetic retinopathy is a major cause of vision loss, particularly in working-age individuals, with two key studies exploring fenofibrate's effects.
- The FIELD study showed that fenofibrate significantly reduced the need for laser treatment in patients with certain types of retinopathy, while the ACCORD-Eye study found it slowed diabetic retinopathy progression in patients using both fenofibrate and statins.
- Overall, there is strong evidence indicating that fenofibrate is effective in slowing diabetic retinopathy progression, leading to its approval in Australia for this use in 2013.
Article Abstract
Background: Diabetic retinopathy is a significant cause of vision impairment, especially affecting those of working age. There are two large, randomised controlled trials examining the effect of fenofibrate on diabetic retinopathy.
Objective: We summarise their findings, and report on the available safety data.
Discussion: The FIELD study reported that patients treated with fenofibrate had a statistically significant relative risk reduction in the need for laser treatment for maculopathy and proliferative retinopathy. The ACCORD-Eye study reported a statistically significant reduction in diabetic retinopathy progression in patients treated with fenofibrate and statin combination therapy compared to statin therapy alone. There is firm evidence that fenofibrate slows the progression of diabetic retinopathy and the need for more invasive treatment modalities in patients with type 2 diabetes, especially those with pre-existing retinopathy. In October 2013, Australia became the first country in the world to approve the use of this medication for this specific indication.
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