AI Article Synopsis
- - The study evaluates the structure of vaccine supply chains in 57 GAVI-eligible countries, examining if these chains are effectively tailored to the specific needs of each country and whether a redesign is necessary.
- - Researchers categorized these supply chains into three clusters based on their characteristics, finding that 34 out of 57 chains follow a four-level model, which doesn't significantly correlate with various national factors.
- - The results indicated that simplified supply chain models, with fewer steps between central distribution points and immunization locations, could lead to lower costs, suggesting a need for less complex and more customized designs in vaccine distribution.
Article Abstract
Background: Many of the world's vaccine supply chains do not adequately provide vaccines, prompting several questions: how are vaccine supply chains currently structured, are these structures closely tailored to individual countries, and should these supply chains be radically redesigned?
Methods: We segmented the 57 GAVI-eligible countries' vaccine supply chains based on their structure/morphology, analyzed whether these segments correlated with differences in country characteristics, and then utilized HERMES to develop a detailed simulation model of three sample countries' supply chains and explore the cost and impact of various alternative structures.
Results: The majority of supply chains (34 of 57) consist of four levels, despite serving a wide diversity of geographical areas and population sizes. These four-level supply chains loosely fall into three clusters [(1) 18 countries relatively more bottom-heavy, i.e., many more storage locations lower in the supply chain, (2) seven with relatively more storage locations in both top and lower levels, and (3) nine comparatively more top-heavy] which do not correlate closely with any of the country characteristics considered. For all three cluster types, our HERMES modeling found that simplified systems (a central location shipping directly to immunization locations with a limited number of Hubs in between) resulted in lower operating costs.
Conclusion: A standard four-tier design template may have been followed for most countries and raises the possibility that simpler and more tailored designs may be warranted.
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| http://dx.doi.org/10.1016/j.vaccine.2015.07.033 | DOI Listing |
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