[Graft-versus-host disease, a rare complication of lung transplantation].

Rev Pneumol Clin

Service de pneumologie, hôpital cardiovasculaire et pneumologique Louis-Pradel, CHU de Lyon, 28, avenue du Doyen-Lépine, 69677 Bron cedex, France; Centre de référence des maladies rares pulmonaires, 69000 Lyon, France; Université Lyon 1, 69007 Lyon, France; INRA, UMR754, 69007 Lyon, France.

Published: February 2016

Graft-versus-host disease (GVHD) is a classic and frequent multisystemic complication of bone marrow allografts. It has also been reported after the transplantation of solid organs such as the liver or gut. Recent cases of GVHD have been reported after lung and heart-lung transplant. Skin, liver, gastrointestinal tract and bone marrow are the organ preferentially affected by GVHD. Corticosteroid is the first line treatment of GVHD. The prognosis reported in solid organ transplants is poor with infectious complications favoured by immunosuppressive therapy. In this article, we report a case of a patient with cystic fibrosis who presented a probable GVHD 18 months after a lung transplant and a literature review of similar cases.

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http://dx.doi.org/10.1016/j.pneumo.2015.05.004DOI Listing

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