AI Article Synopsis
- - Researchers discovered complex polybrominated p-terphenyl ethers from a mushroom (Boletopsis sp.) traditionally used for medicine by the Kiovi people of Papua New Guinea.
- - Boletopsins 13 and 14 are the first known polybrominated metabolites created by a terrestrial fungus.
- - The synthesis method used involves 2,4,4,6-tetrabromo-2,5-cyclohexadienone to selectively polybrominate the aromatic system in a controlled, step-by-step process.
Article Abstract
Here we report the discovery and synthesis of complex polybrominated p-terphenyl ethers isolated from a mushroom (Boletopsis sp.) used as a traditional medicine by the Kiovi people in the highlands of Papua New Guinea. Boletopsins 13 and 14 represent the first report of polybrominated fungal metabolites to be produced by a terrestrial fungus. The synthetic method employs 2,4,4,6-tetrabromo-2,5-cyclohexadienone to achieve selective polybromination of the extended aromatic system in a selective and sequential manner.
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| http://dx.doi.org/10.1021/acs.jnatprod.5b00202 | DOI Listing |
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