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Bone Tissue Engineering: From Biomaterials to Clinical Trials.
Adv Exp Med Biol
January 2025
Department of Stem Cells & Regenerative Medicine, Centre for Interdisciplinary Research, D Y Patil Education Society (Deemed to be University), Kolhapur, India.
Bone tissue engineering is a promising field that aims to rebuild the bone tissue using biomaterials, cells, and signaling molecules. Materials like natural and synthetic polymers, inorganic materials, and composite materials are used to create scaffolds that mimic the hierarchical microstructure of bone. Stem cells, particularly mesenchymal stem cells (MSCs), play a crucial role in bone tissue engineering by promoting tissue regeneration and modulating the immune response.
View Article and Find Full Text PDFTiming in orthopaedic surgery - Rethinking traditional myths with a critical perspective.
Injury
January 2025
Department of Trauma Surgery, University Medical Center Regensburg, Regensburg, Germany; Department of Trauma, Hand- and Reconstructive Surgery, University Hospital Giessen, Giessen, Germany. Electronic address:
Purpose: Standard operating procedures aim to achieve a standardized and assumedly high-quality therapy. However, in orthopaedic surgery, the aspect of temporal urgency is often based on surgical tradition and experience. At a time of evidence-based medicine, it is necessary to question these temporal guidelines.
View Article and Find Full Text PDFPrediction of subsequent vertebral fracture after percutaneous vertebral augmentation using MRI-based vertebral bone quality and CT-based Hounsfield units: a retrospective cross-sectional study.
Sci Rep
January 2025
Department of Orthopaedics, Xuzhou Central Hospital, Xuzhou Clinical School of Xuzhou Medical University, #199 Jiefang South Road, Xuzhou, 221009, JiangSu Province, China.
Subsequent vertebral fracture (SVF) is a common and refractory complication after percutaneous vertebral augmentation (PVA) for osteoporotic vertebral compression fracture (OVCF). Computed tomography (CT)-based Hounsfeld units (HU) and magnetic resonance imaging (MRI)-based vertebral bone quality (VBQ) score can evaluate osteoporosis quantitatively, hyperlipidemia(HLP) might affect measurement result of VBQ score. The primary objective of this study is to compare the predictive capabilities of HU and VBQ for SVF, and to clarify the impact of hyperlipidemia on the predictive abilities.
View Article and Find Full Text PDFEffect of percutaneous vertebroplasty through UTPP approach on prognosis and quality of life in elderly patients with osteoporotic vertebral compression fractures: a retrospective study.
BMC Surg
January 2025
Spinal Surgery, Second Affiliated Hospital of Guangdong Medical University, Zhanjiang, 524000, Guangdong Province, China.
Background: To explore the clinical characteristics of percutaneous vertebroplasty (PVP) via unilateral transverse process-pedicular (UTPP) approach in the treatment of osteoporotic vertebral compression fracture (OVCF) in the elderly.
Methods: A total of 120 elderly patients with lumbar OVCF who underwent PVP via unilateral pedicular (UTP) and UTPP approaches in our hospital from January 2022 to January 2024 were retrospectively analyzed. The postoperative VAS score (visual analog scale), ODI score (Oswestry disability index), surgical indicators, and imaging indicators were recorded in the two groups.
Predicting residual pain after vertebral augmentation in vertebral compression fractures: a systematic review and critical appraisal of risk prediction models.
BMC Musculoskelet Disord
January 2025
Department of Acupuncture and Moxibustion, Affiliated Hospital of Changchun University of Chinese Medicine, Changchun, China.
Background: Patients with vertebral compression fractures may experience unpredictable residual pain following vertebral augmentation. Clinical prediction models have shown potential for early prevention and intervention of such residual pain. However, studies focusing on the quality and accuracy of these prediction models are lacking.
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