Cortical folding and the potential for prognostic neuroimaging in schizophrenia.

Shuixia Guo Sarina Iwabuchi Vijender Balain Jianfeng Feng Peter Liddle Lena Palaniyappan

Br J Psychiatry

Shuixia Guo, PhD, College of Mathematics and Computer Science, Key Laboratory of High Performance Computing and Stochastic Information Processing (Ministry of Education of China), Hunan Normal University, Changsha, PR China and Department of Computer Science, University of Warwick, Coventry, UK; Sarina Iwabuchi, PhD, Division of Psychiatry & Applied Psychology, University of Nottingham and Centre for Translational Neuroimaging, Institute of Mental Health, Nottingham, UK; Vijender Balain, MRCPsych, Penticton Regional Hospital, Penticton, British Columbia, Canada; Jianfeng Feng, PhD, Shanghai Center for Mathematical Sciences, Fudan University, Shanghai, PR China and Department of Computer Science, University of Warwick, Coventry, UK; Peter Liddle, PhD, Division of Psychiatry & Applied Psychology, University of Nottingham and Centre for Translational Neuroimaging, Institute of Mental Health, Nottingham, UK; Lena Palaniyappan, PhD, MRCPsych, Division of Psychiatry & Applied Psychology, University of Nottingham, Centre for Translational Neuroimaging, Institute of Mental Health, Nottingham, UK and Penticton Regional Hospital, Penticton, British Columbia, Canada

Published: November 2015

In 41 patients with schizophrenia, we used neuroanatomical information derived from structural imaging to identify patients with more severe illness, characterised by high symptom burden, low processing speed, high degree of illness persistence and lower social and occupational functional capacity. Cortical folding, but not thickness or volume, showed a high discriminatory ability in correctly identifying patients with more severe illness.

Download full-text PDF	Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4629075	PMC
http://dx.doi.org/10.1192/bjp.bp.114.155796	DOI Listing

Publication Analysis

Top Keywords

cortical folding

patients severe

severe illness

folding potential

potential prognostic

prognostic neuroimaging

neuroimaging schizophrenia

schizophrenia patients

patients schizophrenia

schizophrenia neuroanatomical

Similar Publications

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!