Hydrazones as a privileged structural linker in antitubercular agents: a review.

Infect Disord Drug Targets

Division of Drug Design and Medicinal Chemistry Research Lab, Department of Pharmaceutical Chemistry, Grace; College of Pharmacy, Palakkad-678004, Kerala, India.

Published: May 2016

Hydrazones are a versatile linker of connecting various classes of organic compounds with a unique structural feature of hydrogen bonding donor and the hydrogen bonding acceptor region. An extensive number of research has been carried out on hydrazone derivatives as a potent class of antitubercular agents. The present review focuses on the chemistry, antitubercular activity and structure activity relationship (SAR) of diverse classes of phenyl and heterocyclic based hydrazones.

Download full-text PDF

Source
http://dx.doi.org/10.2174/1871526515666150724104411DOI Listing

Publication Analysis

Top Keywords

antitubercular agents
8
agents review
8
hydrogen bonding
8
hydrazones privileged
4
privileged structural
4
structural linker
4
linker antitubercular
4
review hydrazones
4
hydrazones versatile
4
versatile linker
4

Similar Publications

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!