Double immunofluorescent staining confirmed co-expression of somatostatin (neuropeptide) and antigen-presenting cells of macrophage origin expressing major histocompatibility complex class II molecules in the intact thymus. The results confirmed cooperation of the neuropeptide and immunocompetent systems.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1007/s10517-015-2970-1 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Cross-species analyses of thymic mimetic cells reveal evolutionarily ancient origins and both conserved and species-specific elements.
Immunity
December 2024
Department of Immunology, Harvard Medical School, Boston, MA, USA. Electronic address:
Thymic mimetic cells are molecular hybrids between medullary-thymic-epithelial cells (mTECs) and diverse peripheral cell types. They are involved in eliminating autoreactive T cells and can perform supplementary functions reflective of their peripheral-cell counterparts. Current knowledge about mimetic cells derives largely from mouse models.
View Article and Find Full Text PDFPrimary mediastinal large B-cell lymphoma from the clinic to genomics: Insights for pathologists.
Hum Pathol
December 2024
American University of Beirut, Beirut, Lebanon. Electronic address:
Primary mediastinal large B-cell lymphoma (PMBL) is a mature aggressive B-cell lymphoma that arises in the anterior mediastinum, likely originating from thymic B cells. Initially considered a subtype of diffuse large B-cell lymphoma, PMBL has since been established as a distinct clinicopathologic entity due to its unique clinical, morphologic, immunophenotypic and genetic characteristics. PMBL primarily affects young adults, especially women, and manifests as a bulky mediastinal mass that can invade adjacent structures, often causing respiratory symptoms.
View Article and Find Full Text PDFUnderstanding how the structures of surfactants in hybrid nanoparticles affect the compaction of ct-DNA for cellular uptake: presenting a highly efficient surfactant.
Soft Matter
December 2024
Department of Chemistry, Birla Institute of Technology & Science (BITS) Pilani, Hyderabad Campus, Hyderabad, Telangana 500078, India.
Article Synopsis
- The study compares the DNA compaction efficiency of two single-head-double-tailed surfactants (DDAB16 and DDAB18) and one triple-head-double-tailed surfactant (MQAS12), finding DDAB18 to be the most efficient and MQAS12 the least.
- Hybrid materials combining surfactants with silica nanoparticles show improved compaction efficiency due to cooperative binding, allowing for effective DNA compaction at lower surfactant concentrations, which reduces cytotoxicity.
- The research indicates that the hydrophobicity and structural characteristics of surfactants and nanoparticles significantly influence DNA compaction, supporting the potential design of safe and efficient non-viral vectors for biomedical applications.
Biologics in allergology and clinical immunology: Update on therapies for atopic diseases, urticaria, and angioedema and on safety aspects focusing on hypersensitivity reactions.
Allergol Select
November 2024
Institute of Allergology, Charité Universitätsmedizin Berlin und Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, Allergology and Immunology, Berlin.
Article Synopsis
- Targeted therapies using biologics for atopic diseases, urticaria, and angioedema are advancing quickly, with several new antibodies developed, tested, and approved for clinical use, like omalizumab and dupilumab.
- There is ongoing research into combining different biologics for enhanced treatment efficacy, expanding their applications to conditions like food allergies and eosinophilic esophagitis.
- There are emerging concerns about unexpected side effects and hypersensitivity reactions associated with these therapies, raising important questions about their safety and mechanisms, particularly in specific patient groups like children.
Dietary Zinc Restriction and Chronic Restraint Stress Affect Mice Physiology, Immune Organ Morphology, and Liver Function.
Nutrients
November 2024
Department of Neurobiology, Maj Institute of Pharmacology, Polish Academy of Sciences, ul. Smętna 12, 31-343 Kraków, Poland.
Background: Preclinical and clinical studies suggest that zinc deficiency and chronic stress contribute to depressive symptoms. Our study explores the intricate relationship between these factors by examining their physiological and biochemical effects across various organs in C57Bl/6J mice.
Methods: The mice were divided into four groups: control, chronic restraint stress for 3 weeks, a zinc-restricted diet (<3 mg/kg) for 4 weeks, and a combination of stress and zinc restriction.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!