AI Article Synopsis
- A new method was introduced to measure calcium (Ca²+) activity in human blood serum by observing how well sheep red blood cells are lysed in a specific environment.
- The degree of lysis inhibition is categorized: less than 30% inhibition indicates high Ca²+ activity, 31-70% is normal, and over 71% suggests low activity.
- This method helps assess an individual's immune status by comparing the function of antibody activity and the complement system under certain conditions.
Article Abstract
We proposed a new indicator for evaluation of functional activity of Ca(2+) in human blood serum based on lysis of sheep erythrocytes with 10% human blood serum in the presence of 0.55 mM ethylene glycol tetraacetic acid at 37°C for 10 min. After incubation, the degree of sheep erythrocytes lysis inhibition is estimated: inhibition of complement hemolytic activity <30% is considered as high functional Са(2+) activity, inhibition by 31-70% corresponds to normal activity, and >71% indicates low activity. The comparative studies of complement activating function of heterophilic antibodies, complement system reactivity in the presence of 0.29 M NaCl, and functional activity of ionized Ca(2+) make possible estimation of the individual's immune status.
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| http://dx.doi.org/10.1007/s10517-015-2948-z | DOI Listing |
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