Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Modeling urban pollutant wash-off processes with ecological memory.
J Environ Manage
December 2024
Earth System Science Interdisciplinary Center, University of Maryland, College Park, 5825 University Research Ct, College Park, MD, 20740, USA.
Urbanization increases the extent of impervious surfaces, runoff, sediment, and nutrient loadings downstream, leading to the deterioration of urban surface waters. During pollutant wash-off from urban surfaces, the peak concentration of pollutants typically occurs after the rainfall peak. However, current urban wash-off models do not consider this time delay, assuming that the effect of rainfall on the wash-off process is immediate.
View Article and Find Full Text PDFMultiple DNA repair pathways prevent acetaldehyde-induced mutagenesis in yeast.
Genetics
December 2024
Department of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, SC 29425, USA.
Acetaldehyde is the primary metabolite of alcohol and is present in many environmental sources including tobacco smoke. Acetaldehyde is genotoxic, whereby it can form DNA adducts and lead to mutagenesis. Individuals with defects in acetaldehyde clearance pathways have increased susceptibility to alcohol-associated cancers.
View Article and Find Full Text PDFArticle Synopsis
- The text discusses the importance of forecasting future health issues in the USA for effective planning and public awareness regarding disease and injury burdens.
- It describes the methodology for predicting life expectancy, cause-specific mortality, and disability-adjusted life-years (DALYs) from 2022 to 2050 using the Global Burden of Diseases framework.
- The forecasting includes various scenarios to assess the potential impacts of health risks and improvements across the country, focusing on demographic trends and health-related risk factors.
Repair of replication-dependent double-strand breaks differs between the leading and lagging strands.
Mol Cell
November 2024
Department of Microbiology & Immunology, Columbia University Irving Medical Center, New York, NY 10032, USA; Department of Genetics & Development, Columbia University Irving Medical Center, New York, NY 10032, USA. Electronic address:
Single-strand breaks (SSBs) are one of the most commonly occurring endogenous lesions with the potential to give rise to cytotoxic double-strand breaks (DSBs) during DNA replication. To investigate how replication-dependent DSBs are repaired, we employed Cas9 nickase (nCas9) to generate site- and strand-specific nicks in the budding yeast genome. We found that nCas9-induced nicks are converted to mostly double-ended DSBs during S phase.
View Article and Find Full Text PDFDNA nicks in both leading and lagging strand templates can trigger break-induced replication.
Mol Cell
November 2024
Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, UK. Electronic address:
Article Synopsis
- Replication forks encountering unrepaired single-strand breaks (SSBs) can lead to both single-ended (seDSBs) and double-ended double-strand breaks (deDSBs), which are significant in cancer development.
- The study reveals that in fission yeast, SSBs typically result in deDSBs repaired by homologous recombination, but can also initiate break-induced replication (BIR).
- The occurrence of BIR is more frequent when DNA replication fork convergence is delayed and the Ku70 protein, involved in non-homologous end joining, is absent.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!