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Advances in Drug Delivery Systems for Atopic Dermatitis Treatment.
Chembiochem
December 2024
University of Shanghai for Science and Technology, School of Materials and Chemistry, CHINA.
Atopic dermatitis (AD) is a chronic inflammatory skin disorder characterized by pruritus and impaired skin barrier function. Advances in drug delivery systems have transformed AD treatment by enhancing drug stability, bioavailability, and targeted delivery. Drug delivery systems such as liposomes, hydrogels, and microneedles enable deeper skin penetration, prolonged drug retention, and controlled release, reducing side effects and treatment frequency.
View Article and Find Full Text PDFBiomaterials for Corneal Regeneration.
Adv Sci (Weinh)
December 2024
MOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou, Zhejiang, 310058, China.
Corneal blindness is a significant reason for visual impairment globally. Researchers have been investigating several methods for corneal regeneration in order to cure these patients. Biomaterials are favored due to their biocompatibility and capacity to promote cell adhesion.
View Article and Find Full Text PDFHyaluronic Acid-Based Self-Healing Hydrogels for Diabetic Wound Healing.
Adv Healthc Mater
December 2024
School of Biosciences and Bioengineering, Indian Institute of Technology Mandi, Kamand, Mandi, Himachal Pradesh, 175075, India.
Diabetic wounds, particularly diabetic foot ulcers (DFUs), are significant threats to human well-being due to their impaired healing from poor circulation and high blood sugar, increased risk of infection and potential for severe complications like amputation, all compounded by peripheral neuropathy and chronic inflammation. Most therapies and dressings for DFUs focus on one symptom at a time, however, multifunctional smart self-healing hydrogels can withstand multifactorial motional diabetic wounds. Motional wounds are easy-to-split wounds that experience tension, compression, and movement caused by stress now and then.
View Article and Find Full Text PDFRole of 3D ultrasound in the treatment of stress urinary incontinence with polyacrylamide hydrogel (Bulkamid®) - A pilot study.
Eur J Obstet Gynecol Reprod Biol
December 2024
Department of Obstetrics and Gynecology, Aalborg University Hospital (AAUH), Denmark.
Introduction And Hypothesis: Polyacrylamide hydrogel (PAHG) is a bulking agent used in treatment of stress urinary incontinence (SUI) in women. Some women experience an improvement or cure in stress urinary incontinence (SUI) symptoms lasting only a few weeks after the injection of the bulking agent. The aim of this study was to use three-dimensional ultrasound (3DUS) to describe the changes in volume, number of deposits and echogenicity of the bulking agent 3 months after PAHG injection.
View Article and Find Full Text PDF3D in vitro modelling of post-partum cardiovascular health reveals unique characteristics and signatures following hypertensive disorders in pregnancy.
Biol Sex Differ
November 2024
School of Life Sciences, Faculty of Science, University of Technology Sydney, Sydney, NSW, Australia.
Article Synopsis
- * Researchers used human stem cell-derived heart cells to create cardiac spheroids and exposed them to patient plasma from years after pregnancy to assess how gestational hypertension (GH) and preeclampsia (PE) affect heart cell function and viability.
- * Results showed that both GH and PE increased heart cell contraction rates, with PE also boosting heart cell shortening, while GH reduced cell viability; a proteomic analysis revealed specific proteins linked to heart issues in both conditions.
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