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Increased serum interferon activity in sarcoidosis compared to that in tuberculosis: Implication for diagnosis?
Heliyon
September 2024
Laboratory Medical Immunology, Department of Immunology, Erasmus MC University Medical Center Rotterdam, the Netherlands.
Article Synopsis
- This study investigated serum levels and activity of interferon (IFN) in patients with sarcoidosis and tuberculosis (TB), focusing on those with uveitis, to understand IFN's role in these diseases.
- Serum samples from patients in Indonesia (TB) and the Netherlands (sarcoidosis) were analyzed using specific assays to measure IFN types and activity, as well as the presence of autoantibodies against IFN.
- The results showed significantly higher levels of IFNα2 and IFNγ in sarcoidosis patients compared to TB patients, particularly in those with uveitis, suggesting that IFN may be a useful marker for distinguishing between these two similar conditions.
Evolving Fuchs' uveitis - A diagnostic challenge.
Indian J Ophthalmol
June 2024
Department of Corneal and Refractive Surgery, Narayana Nethralaya, Bengaluru, Karnataka, India.
Purpose: To study cases of Fuchs' uveitis (FU) diagnosed as uveitis other than FU at initial visits.
Methods: A retrospective, observational chart review. Details of clinical presentation, initial diagnosis, treatment details, and follow-up before and after the diagnosis of FU was studied.
Diagnostic efficacy of elevated serum angiotensin-converting enzyme and lymphopenia between presumed sarcoid uveitis and presumed tubercular uveitis.
Int Ophthalmol
October 2023
Director of Uveitis and Ocular Pathology Department, Medical Research Foundation, Sankara Nethralaya, Chennai, India.
Purpose: To evaluate the diagnostic efficacy of elevated serum angiotensin-converting enzyme (sACE) and lymphopenia in presumed sarcoid and tubercular uveitis.
Methods: A single-centre retrospective study was conducted on a cohort of 755 adult patients with uveitis between January 2019 and June 2020. Demographic, clinical and laboratory data were retrieved from our hospital database.
Chronic Tubercular Mediastinitis: A Rare Case Presentation With Subcutaneous Emphysema.
Cureus
May 2023
Respiratory Medicine, Datta Meghe Medical College, Datta Meghe Institute of Medical Sciences, Wardha, IND.
Tuberculosis, histoplasmosis, various fungal infections, malignancy, and sarcoidosis are the most common causes of chronic or slowly progressing mediastinitis. Chronic mediastinitis of tubercular origin with subcutaneous emphysema is exceptionally uncommon, and the majority of cases are caused by trauma. Here we report the case of a 35-year-old chronic alcoholic male who presented to the Outpatient Department (OPD) with complaints of cough, chest pain, loss of weight, and intermittent low-grade fever for three months with no significant past medical history or family history for any respiratory diseases.
View Article and Find Full Text PDFA Case of Coexistent Sarcoidosis and Tuberculosis: A Diagnostic Dilemma.
Cureus
April 2023
Paediatrics Pulmonology, Al Qassimi Women's and Children's Hospital, Sharjah, ARE.
Sarcoidosis and tuberculosis (TB) are chronic granulomatous diseases with similar radiological, clinical, and histopathological presentations. Although rare, both conditions can coexist together. Case reports of concomitant incidence have been published in the literature.
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