The jadomycin-derived compound l-digitoxosyl-phenanthroviridin was isolated from fermentations of Streptomyces venezuelae ISP5230 grown in nutrient-deficient media with l-lysine as the sole nitrogen source. Structural elucidation was accomplished using a combination of high-resolution MS, LC-MS/MS, and 1D- and 2D-NMR. The compound was evaluated against the National Cancer Institute (NCI) 60 human tumor cell line screen in both the one-dose and five-dose screens, and cytotoxicity was compared to a small library of jadomycin analogues to probe the structure-activity relationship.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1021/acs.jnatprod.5b00277 | DOI Listing |
Publication Analysis
Top Keywords
streptomyces venezuelae
8
venezuelae isp5230
8
characterization l-digitoxosyl-phenanthroviridin
4
l-digitoxosyl-phenanthroviridin streptomyces
4
isp5230 jadomycin-derived
4
jadomycin-derived compound
4
compound l-digitoxosyl-phenanthroviridin
4
l-digitoxosyl-phenanthroviridin isolated
4
isolated fermentations
4
fermentations streptomyces
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!