AI Article Synopsis
- The study examined how blocking galanin receptors affects anxiety in rats that experienced psychogenic trauma, created by witnessing a partner's death.
- Administering a galanin receptor antagonist before stress exposure heightened the rats' anxiety and led to behaviors like hypervigilance.
- The findings indicate that galanin plays a protective role in regulating the central nervous system's response to traumatic stress, which could relate to posttraumatic stress disorder.
Article Abstract
Effects of blockage of central galanin receptors on anxiety manifestations were studied in rats with psychogenic trauma. Psychogenic trauma was modeled by exposure of a group of rats to the situation when the partner was killed by a predator. Antagonist of galanin receptors was intranasally administered before stress exposure. Animal behavior was evaluated using the elevated-plus maze test, free exploratory paradigm, and open-field test. Psychogenic trauma was followed by an increase in anxiety level and appearance of agitated behavior. Blockage of galanin receptors aggravated behavioral impairment, which manifested in the pathological anxious reactions - manifestations of hypervigilance and hyperawareness. The results suggest that endogenous pool of galanin is involved into prevention of excessive CNS response to stressful stimuli typical of posttraumatic stress disorder.
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