In coho salmon Oncorhynchus kisutch, no significant differences in critical thermal maximum (c. 26·9° C, CTmax ) were observed among size-matched wild-type, domesticated, growth hormone (GH)-transgenic fish fed to satiation, and GH-transgenic fish on a ration-restricted diet. Instead, GH-transgenic fish fed to satiation had significantly higher maximum heart rate and Arrhenius breakpoint temperature (mean ± s.e. = 17·3 ± 0·1° C, TAB ). These results provide insight into effects of modified growth rate on temperature tolerance in salmonids, and can be used to assess the potential ecological consequences of GH-transgenic fishes should they enter natural environments with temperatures near their thermal tolerance limits.
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http://dx.doi.org/10.1111/jfb.12736 | DOI Listing |
Front Endocrinol (Lausanne)
December 2022
State Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, Innovation Academy for Seed Design, Chinese Academy of Sciences, Hubei Hongshan Laboratory, Wuhan, China.
Growth hormone (GH) is important for regulating insulin secretion and carbohydrate metabolism, and its role in mammalian models of diabetes is relatively worked out. Although some fish species were used as models for diabetes research, the effects of GH on insulin and glucose catabolism and anabolism in these models remain to be clarified. In this study, we investigated the effect of GH on insulin and glucose catabolism and anabolism in an omnivorous fish using transgenic (T) common carp that consistently overexpressed and wild-type (WT) common carp.
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September 2022
State Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, Innovation Academy for Seed Design, Chinese Academy of Sciences, Hubei Hongshan Laboratory, Wuhan, China.
() transgenic common carp ( L.) show desirable aquaculture traits. Their specific growth rate (SGR) and feed efficiency (FE) are approximately 12% and 17% higher than the wild-type (WT) common carp, respectively.
View Article and Find Full Text PDFJ Exp Biol
October 2022
Cell Biology, Physiology, and Immunology Department, School of Biology, University of Barcelona, 643 08028 Barcelona, Catalonia, Spain.
In fish otoliths, CaCO3 normally precipitates as aragonite, and more rarely as vaterite or calcite. A higher incidence of vaterite deposition in otoliths from aquaculture-reared fish has been reported and it is thought that high growth rates under farming conditions might promote its deposition. To test this hypothesis, otoliths from growth hormone (GH) transgenic coho salmon and non-transgenic fish of matching size were compared.
View Article and Find Full Text PDFSci Rep
April 2022
Department of Marine Science and Resources, Nihon University College of Bioresource Sciences, Kameino 1866, Fujisawa, 252-0880, Japan.
Growth hormone (GH) transgenesis can be used to manipulate the growth performance of fish and mammals. In this study, homozygous and hemizygous GH-transgenic amago salmon (Oncorhynchus masou ishikawae) derived from a single female exhibited hypoglycemia. Proteomic and signal network analyses using iTRAQ indicated a decreased NAD/NADH ratio in transgenic fish, indicative of reduced mitochondrial ND1 function and ROS levels.
View Article and Find Full Text PDFSci Rep
January 2022
School of Fisheries, Aquaculture and Aquatic Sciences, Auburn University, Auburn, AL, 36849, USA.
Fish is an essential source of high-quality protein for people worldwide. The present study was designed to compare the growth performance among the channel-blue hybrid catfish, channel catfish transgenic for the channel catfish growth hormone (ccGH) cDNA driven by the antifreeze protein promoter from an ocean pout Zoarces americanus (opAFP-ccGH), and non-transgenic channel catfish control. Mean body weight of channel-blue hybrid catfish was 15.
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