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| http://dx.doi.org/10.5812/ijp.25(3)2015.533 | DOI Listing |
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Cortisol regulates neonatal lung development via Smoothened.
Respir Res
January 2025
National Clinical Research Center for Aging and Medicine, State Key Laboratory of Medical Neurobiology, Huashan Hospital, Fudan University, Shanghai, 200040, China.
Background: Neonatal respiratory distress syndrome (NRDS), one of the main causes of neonatal death, is clinically characterized by progressive dyspnea and cyanosis 1 to 2 h after birth. Corticosteroids are commonly used to prevent NRDS in clinical. However, the protective mechanism of the corticosteroids remains largely unclear.
View Article and Find Full Text PDFUnderstanding stakeholder perspectives on Apgar score, cyanosis and identifying jaundice in ethnic minority neonates.
PLoS One
October 2024
Sheffield Hallam University, Sheffield, United Kingdom.
Article Synopsis
- The study aims to evaluate how healthcare professionals assess the skin colors of neonates from Black, Asian, and minority ethnic backgrounds, specifically focusing on the Apgar score, cyanosis, and jaundice.
- The research involved interviews with healthcare professionals and parents of these infants, revealing inconsistencies in the application of the Apgar score and challenges in identifying jaundice and cyanosis in darker skin tones.
- The findings indicate a need for standardized protocols and enhanced training for healthcare professionals to improve neonatal assessments across diverse ethnicities.
A disproportionality analysis of adverse events associated to pertuzumab in the FDA Adverse Event Reporting System (FAERS).
BMC Pharmacol Toxicol
November 2023
Department of Pharmacy, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, No.1095 Jiefang Avenue, Wuhan, Hubei Province, 430000, China.
Background: Pertuzumab is widely used for the treatment of HER2 + breast cancer. But its safety in the real world should be continuously monitored. So, we evaluated the safety of pertuzumab by pharmacovigilance analyze based on related adverse events (AEs) from the FDA Adverse Event Reporting System (FAERS) and find whether potential or uncertain adverse events were present.
View Article and Find Full Text PDFQinhuo Shanggan oral solution resolves acute lung injury by down-regulating TLR4/NF-B signaling cascade and inhibiting NLRP3 inflammasome activation.
Front Immunol
November 2023
State Key Laboratory of Southwestern Chinese Medicine Resources, Department of Pharmacology, School of Pharmaceutical Sciences, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Acute lung injury (ALI) is a common condition, particularly in the COVID-19 pandemic, which is distinguished by sudden onset of respiratory insufficiency with tachypnea, oxygen-refractory cyanosis, reduced lung compliance and diffuse infiltration of pulmonary alveoli. It is well-established that increasing activity of toll-like receptor 4 (TLR4)/nuclear factor kappa-B (NF-B) signaling axis and the NOD-, LRR- and pyrin domain-containing protein 3 (NLRP3) inflammasome activation are associated with the pathogenesis of ALI. Since ALI poses a huge challenge to human health, it is urgent to tackle this affliction with therapeutic intervention.
View Article and Find Full Text PDFDisease severity, arrhythmogenesis, and fibrosis are related to longer action potentials in tetralogy of Fallot.
Clin Res Cardiol
May 2024
Institute for Experimental Cardiovascular Medicine, Faculty of Medicine, University Heart Center Freiburg-Bad Krozingen, University of Freiburg, Freiburg, Germany.
Background: Arrhythmias may originate from surgically unaffected right ventricular (RV) regions in patients with tetralogy of Fallot (TOF). We aimed to investigate action potential (AP) remodelling and arrhythmia susceptibility in RV myocardium of patients with repaired and with unrepaired TOF, identify possible correlations with clinical phenotype and myocardial fibrosis, and compare findings with data from patients with atrial septal defect (ASD), a less severe congenital heart disease.
Methods: Intracellular AP were recorded ex vivo in RV outflow tract samples from 22 TOF and three ASD patients.
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