A new diketopiperazine (DKP) derivative, (6R,3Z)-3-benzylidene-6-isobutyl-1-methyl piperazine-2,5-dione (1), as well as five known DKPs 2-6 was isolated from a deep sea-derived Streptomyces sp. SCSIO 04496. The structure of 1 was elucidated using a combination of 1D and 2D NMR, HR-ESI-MS and chiral-phase HPLC techniques. Compounds 1-6 did not show cytotoxic activity at a concentration of 100 μM in bioactivity assay.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1080/14786419.2015.1045509 | DOI Listing |
Publication Analysis
Top Keywords
deep sea-derived
8
sea-derived streptomyces
8
streptomyces scsio
8
scsio 04496
8
diketopiperazine derivative
4
derivative deep
4
04496 diketopiperazine
4
diketopiperazine dkp
4
dkp derivative
4
derivative 6r3z-3-benzylidene-6-isobutyl-1-methyl
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!