Two new scalarane sesterterpenes (1, 2) were characterized from an organic extract of a single specimen of the nudibranch Glossodoris hikuerensis collected from Bali. 12-Acetoxy dendrillolide A (10) was identified from specimens of Goniobranchus albonares, while dendrillolide A (11) was isolated both from G. albonares and its sponge diet. The structures and relative configuration of the new metabolites have been elucidated by analysis of their spectroscopic data.
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Mar Drugs
September 2023
Research Center for Marine Drugs, State Key Laboratory of Oncogenes and Related Genes, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China.
Eight new scalarane sesterterpenes, phyllofenones F-M (-), together with two known analogues, carteriofenones B and A (-), were isolated from the marine sponge collected from the South China Sea. The structures of these compounds were determined based on extensive spectroscopic and quantum chemical calculation analysis. The antibacterial and cytotoxic activity of these compounds was evaluated.
View Article and Find Full Text PDFJ Nat Prod
July 2023
Research Center for Marine Drugs, State Key Laboratory of Oncogenes and Related Genes, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China.
Phyllospongianes A-E (-), five new scalarane derivatives featuring an unprecedented 6/6/6/5 tetracyclic dinorscalarane scaffold, along with the known probable biogenetic precursor, 12-deacetylscalaradial (), were isolated from the marine sponge . The structures of the isolated compounds were determined by analysis of spectroscopic data and electronic circular dichroism experiments. Compounds - are the first 6/6/6/5 tetracyclic scalarane derivatives to be reported within the scalarane family.
View Article and Find Full Text PDFJ Nat Prod
February 2023
Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, People's Republic of China.
Sarcotragusolides A-D (-), four new butenolide sesterterpenes featuring a rare methyl-transferred 6/6/6-tricyclic fused ring system with a butyrolactone moiety, and echinohalimane B (), an unprecedented monocyclic diterpenoid featuring a 2,7-ring-opened halimane-type skeleton, were isolated from the sponge sp. A γ-hydroxybutenolide sesterterpene derivative (), a new scalarane sesterterpene (), a new subersin-type diterpenoid (), and two known terpenoids were also isolated and identified. The discovery of sarcotragusolides C and D ( and ) with an unprecedented inversion of configuration implied a distinct biosynthetic pathway.
View Article and Find Full Text PDFJ Asian Nat Prod Res
November 2022
Shandong Laboratory of Yantai Drug Discovery, Bohai Rim Advanced Research Institute for Drug Discovery, Yantai 264117, China.
Two new scalarane sesterterpenes, hyrtiosins F and G ( and ), along with two known related compounds, hyrtiosin D and sesterstatin 6 ( and ), were isolated from the Hainan marine sponge The structures of new compounds and were determined by detailed analysis of 1D and 2D NMR spectra and by comparison of the spectroscopic data with those reported in the literatures.
View Article and Find Full Text PDFMar Drugs
November 2022
Korea Institute of Ocean Science & Technology (KIOST), Busan 49111, Republic of Korea.
A chemical investigation of a methanol extract of sp., a marine sponge collected from the Philippines, identified 12 unreported scalarane-type alkaloids-scalimides A-L (-)-together with two previously described scalarin derivatives. The elucidation of the structure of the scalaranes based on the interpretation of their NMR and HRMS data revealed that - featured a -alanine-substituted E-ring but differed from each other through variations in their oxidation states and substitutions occurring at C16, C24, and C25.
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