Macrolide-resistant Mycoplasma pneumoniae (MRMP) is highly prevalent in Asia and is now being reported from Europe. Few data on MRMP are available in the United States. Using genotypic and phenotypic methods, we detected high-level MRMP in 13.2% of 91 M. pneumoniae--positive specimens from 6 US locations.
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http://dx.doi.org/10.3201/eid2108.150273 | DOI Listing |
J Glob Antimicrob Resist
December 2024
Praxis Prenzlauer Berg, Berlin, Germany.
Objectives: The cell wall-less species Mycoplasma genitalium is a sexually transmitted pathogen with strong tendency to acquire resistance. Current knowledge about trends of resistance rates and differences between the risk population of men who have sex with men (MSM) and heterosexual patients as well as about circulating genotypes in both groups is limited.
Methods: Between August 2017 and December 2023, M.
Curr Opin Infect Dis
December 2024
Department of Medicine, NYP/Weill Cornell Medical Center, New York, New York, USA.
Purpose Of Review: Define the utility of adjunctive macrolide therapy in patients with more severe forms of community-acquired pneumonia (CAP).
Recent Findings: Guidelines recommend adjunctive macrolide therapy as an option for patients with CAP, admitted to the hospital. A large data set collected both retrospectively and prospectively, including several recent randomized controlled trials (RCTs) have shown that adjunctive macrolide therapy can reduce mortality and improve outcomes in patients with severe CAP, more effectively than other alternative therapies.
Sex Health
December 2024
Virology and Immunology Department, LabPlus, Auckland City Hospital, Auckland, New Zealand.
Background New Zealand has among the highest rates of antimicrobial resistance in Mycoplasma genitalium in the world. The aim of this study was to correlate treatment outcomes with 23S rRNA and parC mutations associated with macrolide and fluroquinolone resistance, respectively, in a cohort of sexual health clinic patients. Methods Laboratory and clinical data were collected for patients with M.
View Article and Find Full Text PDFInfect Drug Resist
November 2024
Department of Infectious Disease, Children's Hospital of Zhejiang University School of Medicine, National Clinical Research Center for Child Health, National Children's Regional Medical Center, Hangzhou, Zhejiang, People's Republic of China.
Zhongguo Dang Dai Er Ke Za Zhi
November 2024
Hubei Maternal and Child Health Care Hospital, Wuhan 430016, China.
Objectives: To detect multidrug resistance gene locus mutations in children with pneumonia through targeted high-throughput sequencing and to explore its clinical significance.
Methods: A retrospective analysis was conducted on the clinical data of 2 899 children with pneumonia, who underwent respiratory pathogen-targeted high-throughput sequencing, treated at Hubei Maternal and Child Health Care Hospital between January and December 2023. The patients were divided into a mutation group (=885) and a non-mutation group (=2 014) based on whether there was a mutation in the 23SrRNA macrolide-resistant gene of .
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