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Desmoid tumour: a rare cause of congenital unilateral calf enlargement mimicking calf hypertrophy.
Neuromuscul Disord
December 2024
The John Walton Muscular Dystrophy Research Centre (JWMDRC), Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, United Kingdom; Newcastle Hospitals NHS Foundation Trust, Newcastle upon Tyne, United Kingdom; Newcastle University Translational and Clinical Research Institute, Newcastle upon Tyne, United Kingdom.
Desmoid tumours, also known as aggressive fibromatosis, are rare tumours derived from mesenchymal stem cells, accounting for only 0.03 % of all tumours. While 85-90 % of cases are sporadic, desmoid tumours can occasionally be associated with Gardner syndrome (or Familial Adenomatous Polyposis), which is linked to variants in the tumour suppressor gene, APC (adenomatous polyposis coli) gene on chromosome 5.
View Article and Find Full Text PDFReliability of the repetition-to-fatigue method for estimating one-repetition maximum in unilateral strength exercises and its relationship with gait tests in people with multiple sclerosis.
Arch Phys Med Rehabil
December 2024
Sports Research Centre, Department of Sport Sciences, Miguel Hernández University, Elche, Avda. de la Universidad s/n, 03202, Alicante, Spain; Institute for Health and Biomedical Research (ISABIAL Foundation), Miguel Hernández University of Elche, Avda. Pintor Baeza 12-Planta 5a Centro de Diagnóstico, 03010, Alicante, Spain.
Objective: to analyze the reliability of the estimated one-repetition maximum (e1RM) through the repetition to fatigue method in four unilateral resistance training exercises performed using weight machines (i.e., leg press, calf raises, leg extension, seated leg curl), and their relationship to gait-related tests.
View Article and Find Full Text PDFIdentification of a de novo missense variant in the BRI3BP gene in a Holstein calf with congenital cardiac malformation and carpus valgus.
Anim Genet
February 2025
Clinic for Ruminants, Department of Clinical Veterinary Medicine, Vetsuisse Faculty, University of Bern, Bern, Switzerland.
Article Synopsis
- Congenital malformations in cattle, like those seen in a Holstein calf with heart defects and carpus valgus, present diagnostic difficulties and have limited treatment options.
- The study involved using whole genome sequencing to identify a genetic cause, discovering a harmful variant in the BRI3BP gene that was only found in the affected calf and not in its parents or over 5100 other cattle genomes.
- This research highlights the importance of the BRI3BP gene in heart and bone development, and it could provide insights for understanding similar genetic conditions in humans.
Plantar flexor strength and size decrease following single-leg disuse in uninjured adults: A meta-analysis.
Clin Physiol Funct Imaging
January 2025
School of Kinesiology and Health Studies, Queen's University, Kingston, Ontario, Canada.
Introduction: Plantar flexors play a pivotal role in human locomotion and balance. Several original research studies and systematic reviews have characterised the impact of single-leg disuse on plantar flexor strength and size. However, no meta-analysis has quantified the effects of single-leg disuse on changes in plantar flexor strength and size in uninjured adults.
View Article and Find Full Text PDFEffects of metformin phonophoresis and exercise therapy on pain, range of motion, and physical function in chronic knee osteoarthritis: randomized clinical trial.
J Orthop Surg Res
October 2024
Department of Physical Therapy for Musculoskeletal Disorders and its Surgeries, Faculty of Physical Therapy, Cairo University, Cairo, Egypt.
Background: Knee osteoarthritis (KOA) is a common musculoskeletal disorder. Therapeutic ultrasound (US) is a safe and effective treatment for KOA. It relieves knee pain and enhances function.
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