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Ultrasound-assisted dieckol extraction from Eisenia bicyclis and its evaluation as a functional ingredient for bacterial cellulose-based desserts.
Int J Biol Macromol
January 2025
Department of Biotechnology, Sangmyung University, Seoul 03016, Republic of Korea. Electronic address:
Dieckol is a brown algal phlorotannin with potent bioactivities such as hepatoprotective effects. This study aimed to produce dieckol-rich extract from Eisenia bicyclis and apply them as a functional ingredient for a novel bacterial cellulose (BC)-based dessert. The modeling and optimization of the ultrasound-assisted extraction (UAE) process were performed.
View Article and Find Full Text PDFA Pharmacokinetic and Bioavailability Study of Phlorotannins Following Intravenous and Oral Administration in Sprague-Dawley Rats.
Mar Drugs
November 2024
Center for Molecular Intelligence, The State University of New York Korea, Incheon 21985, Republic of Korea.
This study examines the pharmacokinetics and bioavailability of phlorotannins from in rats following intravenous and oral administration. Known for their potent antioxidant, anti-inflammatory and many other bioactivities, these phlorotannins, particularly dieckol, 8,8'-bieckol, and phlorofucofuroeckol-A (PFF-A), were analyzed using high-performance liquid chromatography coupled with tandem mass spectrometry. Intravenous administration at 10 mg/kg allowed detectability in plasma for up to 36 h for dieckol and 8,8'-bieckol, but only 2 h for PFF-A.
View Article and Find Full Text PDFDeciphering inhibitory activity of marine algae Ecklonia cava phlorotannins against SARS CoV-2 main protease: A coupled in-silico docking and molecular dynamics simulation study.
Gene
October 2024
School of Basic Sciences, Indian Institute of Technology Bhubaneswar, Bhubaneswar, India. Electronic address:
The onset of COVID-19 due to the SARS CoV-2 virus has spurred an urgent need for potent therapeutics and vaccines to combat this global pandemic. The main protease (Mpro) of the virus, crucial in its replication, has become a focal point in developing anti-COVID-19 drugs. The cysteine protease Mpro in SARS CoV-2 bears a significant resemblance to the same protease found in SARS CoV-1.
View Article and Find Full Text PDFPhlorotannins: Novel Orally Administrated Bioactive Compounds That Induce Mitochondrial Dysfunction and Oxidative Stress in Cancer.
Antioxidants (Basel)
September 2023
Nutrition and Dietetic School, Facultad de Medicina, Universidad Finis Terrae, Santiago 7501015, Chile.
Mitochondrial dysfunction is an interesting therapeutic target to help reduce cancer deaths, and the use of bioactive compounds has emerged as a novel and safe approach to solve this problem. Here, we discuss the information available related to phlorotannins, a type of polyphenol present in brown seaweeds that reportedly functions as antioxidants/pro-oxidants and anti-inflammatory and anti-tumorigenic agents. Specifically, available evidence indicates that dieckol and phloroglucinol promote mitochondrial membrane depolarization and mitochondria-dependent apoptosis.
View Article and Find Full Text PDFTherapeutic effects of phlorotannins in the treatment of neurodegenerative disorders.
Front Mol Neurosci
May 2023
Department of Neuroscience, City University of Hong Kong, Kowloon, Hong Kong SAR, China.
Phlorotannins are natural polyphenolic compounds produced by brown marine algae and are currently found in nutritional supplements. Although they are known to cross the blood-brain barrier, their neuropharmacological actions remain unclear. Here we review the potential therapeutic benefits of phlorotannins in the treatment of neurodegenerative diseases.
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