AI Article Synopsis
- The study focused on creating oral granules that remain solid until they absorb water, allowing for easier swallowing for patients taking medication.
- Three key polymers—gelatin (GEL), succinylated gelatin (SUC-GEL), and ι-carrageenan (CAR)—were used to develop these gelling granules, which can gel at room temperature.
- The optimal formulation involved using SUC-GEL as the base, combined with polyethylene glycol (PEG) and xylitol (XYL), which enhanced the granules' elasticity and water absorption properties.
Article Abstract
We investigated the preparation of oral granules that are solid when stored and that will swell and gel via water absorption, to address problems experienced by patients when taking medication. Important physical properties of gelling granules include elasticity that is normally smooth, quick water absorption and swelling properties that allow easy swallowing. We selected gelatin (GEL), succinylated gelatin (SUC-GEL) and ι-carrageenan (CAR) as matrix polymers that can undergo gelation at room temperature or at cold temperatures. Saccharide and polyethylene glycol (PEG) were added to prepare the experimental granules. The best matrix gelling granule was SUC-GEL. When xylitol (XYL), sorbitol (SOR) and maltitol (MAL) were added, elasticity was improved, and PEG improved the granule's water absorption behavior, which is an important element involved in gelation. The best granules were prepared by selecting SUC-GEL as the matrix and adding a small amount of PEG and XYL in amounts equal to that of SUC-GEL.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.5582/ddt.2015.01039 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!