AI Article Synopsis
- The study investigates the HPA-axis, a key stress response system, in relation to familial longevity, comparing 24-hour plasma ACTH and cortisol levels in offspring of long-lived siblings to age-matched controls.
- Despite observing higher basal ACTH levels in male offspring, other parameters of HPA-axis activity and its regulation showed no significant differences between the two groups.
- Results indicate that while familial longevity might not correlate with major differences in HPA-axis function at rest, there are minor, sex-specific variations worth further exploration.
Article Abstract
Objective: The hypothalamic-pituitary-adrenal (HPA)-axis is the most important neuro-endocrine stress response system of our body which is of critical importance for survival. Disturbances in HPA-axis activity have been associated with adverse metabolic and cognitive changes. Humans enriched for longevity have less metabolic and cognitive disturbances and therefore diminished activity of the HPA axis may be a potential candidate mechanism underlying healthy familial longevity. Here, we compared 24-h plasma ACTH and serum cortisol concentration profiles and different aspects of the regulation of the HPA-axis in offspring from long-lived siblings, who are enriched for familial longevity and age-matched controls.
Design: Case-control study within the Leiden Longevity study cohort consisting of 20 middle-aged offspring of nonagenarian siblings (offspring) together with 18 partners (controls).
Methods: During 24 h, venous blood was sampled every 10 minutes for determination of circulatory ACTH and cortisol concentrations. Deconvolution analysis, cross approximate entropy analysis and ACTH-cortisol-dose response modeling were used to assess, respectively, ACTH and cortisol secretion parameters, feedforward and feedback synchrony and adrenal gland ACTH responsivity.
Results: Mean (95% Confidence Interval) basal ACTH secretion was higher in male offspring compared to male controls (645 (324-1286) ngl/L/24 h versus 240 (120-477) ng/L/24 h, P = 0.05). Other ACTH and cortisol secretion parameters did not differ between offspring and controls. In addition, no significant differences in feedforward and feedback synchrony and adrenal gland ACTH responsivity were observed between groups.
Conclusions: These results suggest that familial longevity is not associated with major differences in HPA-axis activity under resting conditions, although modest, sex-specific differences may exist between groups that might be clinically relevant.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4508039 | PMC |
| http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0133119 | PLOS |
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