AI Article Synopsis
- Three new sulfated steroid monoglycosides, leptaochotensosides A-C, and a new sulfated polyhydroxylated steroid were identified from the alcoholic extract of the starfish Leptasterias ochotensis.
- The structures of these compounds were determined using advanced techniques like NMR and mass spectrometry.
- Leptaochotensoside A showed potential cancer-preventive effects by inhibiting colony formation in certain cancer cell lines and regulating the MAPK signaling pathway, despite not being cytotoxic at tested doses.
Article Abstract
Three new sulfated steroid monoglycosides, leptaochotensosides A-C (1-3), and a new sulfated polyhydroxylated steroid (4) were isolated from the alcoholic extract of the Far Eastern starfish Leptasterias ochotensis. The structures of compounds 1-4 were established by extensive nuclear magnetic resonance (NMR) and electrospray ionization mass spectrometry (ESIMS) analyses and chemical transformations. Although the isolated compounds did not show any apparent cytotoxicity against melanoma RPMI-7951 and breast cancer T-47D cell lines, leptaochotensoside A (1) demonstrated inhibition of T-47D cell colony formation in a soft agar clonogenic assay at nontoxic doses. In addition, this compound decreased the epidermal growth factor (EGF)-induced colony formation of mouse epidermal JB6 Cl41 cells. The cancer preventive action of 1 is realized through regulation of mitogen-activated protein kinase (MAPK) signaling pathway.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4515625 | PMC |
| http://dx.doi.org/10.3390/md13074418 | DOI Listing |
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