AI Article Synopsis
- The study compares the effects of two weight loss surgeries (Roux-en-Y gastric bypass and sleeve gastrectomy) and intensive medical therapy on body composition in type 2 diabetes patients over two years.
- Both surgical methods led to similar weight loss results that were better than medical therapy, but resulted in about a 10% reduction in lean body mass, 8% reduction in bone mineral content, and 9% reduction in hip bone mineral density.
- The findings suggest that while weight loss surgeries effectively reduce body weight, they also contribute to significant bone loss, highlighting the need for monitoring bone health in these patients.
Article Abstract
Objective: To determine the 2-year outcomes of Roux-en-Y gastric bypass (RYGB) and sleeve gastrectomy (SG) vs. intensive medical therapy (IMT) on lean body mass, total bone mass, and bone mineral density (BMD) measures from the STAMPEDE trial.
Methods: 54 subjects (BMI: 36 ± 1 kg/m(2) , age: 48 ± 4 years) with type 2 diabetes (T2DM) (HbA1c : 9.7 ± 2%) were randomized to IMT, RYGB, or SG and underwent DXA at baseline and at 1 and 2 years.
Results: At 2 years, the reduction in BMI was similar after RYGB and SG and was greater than IMT (P < 0.001). Lean mass was reduced by ∼10%, total bone mineral content reduced by ∼8%, and hip BMD reduced by ∼9% in both surgical groups and was significantly greater than IMT despite increases in vitamin D intake in all groups. The change in hip BMD correlated with weight loss (r = 0.84, P < 0.0001) and changes in lean mass (r = 0.74, P < 0.0001) and leptin (r = 0.53, P < 0.0001). Peripheral fractures were self-reported in RYGB (4/18 patients), SG (2/19 patients), and IMT (4/16 patients).
Conclusions: Surgically induced weight loss is associated with modest reductions in lean mass, bone mineral content, and BMD, despite calcium and vitamin D supplementation in patients with T2DM. Awareness for bone loss is indicated for patients undergoing bariatric procedures.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4701611 | PMC |
| http://dx.doi.org/10.1002/oby.21150 | DOI Listing |
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