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Elegant and Innovative Recoding Strategies for Advancing Vaccine Development.
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Department of Veterinary Microbiology and Immunology, Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon, SK S7N 5E2, Canada.
Recoding strategies have emerged as a promising approach for developing safer and more effective vaccines by altering the genetic structure of microorganisms, such as viruses, without changing their proteins. This method enhances vaccine safety and efficacy while minimizing the risk of reversion to virulence. Recoding enhances the frequency of CpG dinucleotides, which in turn activates immune responses and ensures a strong attenuation of the pathogens.
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Antimicrobial Resistance, Omics and Microbiota Group, Centre for Systems Health and Integrated Metabolic Research, Department of Biosciences, Nottingham Trent University, Nottingham, United Kingdom.
is an unusual diderm firmicute that plays a central role in the formation of dental biofilm formation through coaggregation with many other oral bacteria. However, the molecular interactions leading to oral biofilm formation are largely unknown. In a recent study (L.
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Department of Experimental and Clinical Medicine, University of Florence, Firenze, Italy.
Editorial: When streptococci seize the opportunity: identifying how manipulation of host inflammatory signaling impacts pathogenesis in streptococcal infections.
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Department of Microbiology and Molecular Genetics, Michigan State University, East Lansing, MI, United States.
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Department of Medical Sciences, Molecular Epidemiology and Science for Life Laboratory, Uppsala University, Sweden (S.S.-B., K.F.D., T.F.).
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