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Sialic acids, existing as terminal sugars of glycoconjugates, play important roles in various physiological and pathological processes, such as cell-cell adhesion, immune defense, tumor cell metastasis, and inflammation. Sialyltransferases (STs) catalyze the transfer of sialic acid residues to non-reducing oligosaccharide chains of proteins and lipids, using cytidine monophosphate N-acetylneuraminic acid (CMP-Neu5Ac) as the donor. Elevated sialyltransferase activity leads to overexpression of cell surface sialic acids and contributes to many disease developments, such as cancer and inflammation. Therefore, sialyltransferases are considered as potential drug targets for disease treatment. Inhibitors of sialyltransferases thus are of medicinal interest, especially for the cancer therapy. In addition, sialyltransferase inhibitors are useful tool to study sialyltransferase function and related mechanisms. This review highlights recent development of inhibitors of sialyltransferases reported since 2004. The inhibitors are summarized as eight groups: 1) sialic acid analogs, 2) CMP-sialic acid analogs, 3) cytidine analogs, 4) oligosaccharide derivatives, 5) aromatic compounds, 6) flavonoids, 7) lithocholic acid analogs, and 8) others. This article is part of a Special Issue entitled: Physiological Enzymology and Protein Functions.
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http://dx.doi.org/10.1016/j.bbapap.2015.07.007 | DOI Listing |
Ann Ital Chir
March 2025
Department of Orthopedics, Dongtai People's Hospital, 224200 Yancheng, Jiangsu, China.
Aim: To evaluate the postoperative analgesic efficacy and safety of ketorolac tromethamine in tibial plateau fracture (TPF) patients undergoing open reduction and internal fixation (ORIF) surgery.
Methods: This retrospective cohort study included 194 TPF patients treated at Dongtai People's Hospital between October 2022 and March 2024. Patients meeting the inclusion criteria were divided into two groups: the ketorolac tromethamine group (n = 104), who received ketorolac tromethamine combined with imrecoxib, and the control group (n = 90), who received imrecoxib alone after ORIF.
Int J Surg Case Rep
March 2025
Orthopaedics and Traumatology Department, Hasan Sadikin Hospital, Padjajaran University, Bandung, Indonesia.
Introduction And Importance: Bone metastases are common in advanced malignancies, particularly from breast and prostate cancers, leading to significant morbidity due to pain, functional impairment, and skeletal-related events. This case report discusses a multidisciplinary approach using minimally invasive techniques for managing a challenging supracetabular metastatic lesion.
Case Presentation: A 46-year-old female with metastatic bone disease in the right supracetabular pelvic region secondary to primary breast cancer presented with severe pain (Numeric Analog Scale [NAS] 7-8) and functional impairment.
World J Surg Oncol
March 2025
Section of Esophageal and Mediastinal Oncology, Department of Thoracic Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Background: A blood-based approach to monitor metastasis and recurrence of esophageal squamous cell carcinoma (ESCC) remains undeveloped. This study aimed to establish a dependable model utilizing cfDNA 5-hydroxymethylcytosines (5hmC) signatures to detect these conditions in ESCC.
Methods: The 5hmC-Seal technique was employed to generate comprehensive 5hmC profiles from the plasma cell-free DNA (cfDNA) of 122 ESCC patients, classified into 72 with metastasis, 50 without metastasis, 30 with recurrence, and 92 without recurrence.
Food Chem
March 2025
Laboratory of Micro & Nano Biosensing Technology in Food Safety, Hunan Provincial Key Laboratory of Food Science and Biotechnology, College of Food Science and Technology, Hunan Agricultural University, Changsha 410128, PR China. Electronic address:
Multifunctional Prussian blue analogs (PBAs) have received extensive attention in the detection and degradation of food hazards. However, the development of new structural adjustment strategies to further improve their performance remains a huge challenge. Herein, the "interface recombination" post-processing approach was established to regulate the structure of PBAs using a microwave-assisted solvothermal method combined with acid etching.
View Article and Find Full Text PDFAngew Chem Int Ed Engl
March 2025
Yangzhou University, College of Chemistry and Chemical Engineering, Siwangting road, NO.180, 225002, Yangzhou, CHINA.
In situ composite methods have aroused research interest in materials science and acted as a novel strategy to achieve structural tailoring of materials. However, the controllable preparation of composites containing functional groups remains a challenge. Herein, we report an approach based on competitive coordination between structural analogues, by which the functionally composite metal complex (NiSH@Ni-FSA) was synthesized.
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