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Division of Molecular Diagnostic Pathology, Department of Pathology, School of Medicine, Iwate Medical University, 19-1 Uchimaru, Morioka, 020-8505, Japan.
Published: August 2009
AI Article Synopsis
* An autopsy case detailed in the text showed a patient who experienced acute liver failure, complicated by disseminated intravascular coagulation, leading to rapid liver deterioration before death.
* Histopathological examination revealed significant liver damage, including necrosis, inflammation, and the presence of blood clots in the liver's blood vessels, with death primarily resulting from the liver failure and related complications.
Article Abstract
Scrub typhus (Tsutsugamushi disease) is an acute febrile disease caused by infection with Orientia tsutsugamushi transmitted by mites. Although patients with scrub typhus commonly display mild liver injury, few die of acute liver failure. We describe herein an autopsy case of acute liver failure due to scrub typhus, which was complicated by disseminated intravascular coagulation and showed rapid progression of liver injury just before death. Histopathological findings revealed submassive hepatocellular necrosis, inflammatory cell infiltration in Glisson's capsules, and sporadic fibrin thrombi in the hepatic sinusoids. Cause of death was primarily associated with acute liver failure related to disseminated intravascular coagulation.
