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Characterization of RAP Signal Patterns, Temporal Relationships, and Artifact Profiles Derived from Intracranial Pressure Sensors in Acute Traumatic Neural Injury.
Sensors (Basel)
January 2025
Department of Biomedical Engineering, Price Faculty of Engineering, University of Manitoba, Winnipeg, MB R3T 2N2, Canada.
Goal: Current methodologies for assessing cerebral compliance using pressure sensor technologies are prone to errors and issues with inter- and intra-observer consistency. RAP, a metric for measuring intracranial compensatory reserve (and therefore compliance), holds promise. It is derived using the moving correlation between intracranial pressure (ICP) and the pulse amplitude of ICP (AMP).
View Article and Find Full Text PDFPurpose in Life After Brain Injury: Expanding the Focus and Impact of Interdisciplinary Rehabilitation.
Am J Speech Lang Pathol
January 2025
Allina Health, Courage Kenny Rehabilitation Institute, Minneapolis, MN.
Purpose: Traumatic brain injury (TBI) is a life-altering event that can abruptly and drastically derail an individual's expected life trajectory. While some adults who have sustained a TBI go on to make a full recovery, many live with persisting disability many years postinjury. Helping patients adjust to and flourish with disability that may persist should be as much a part of rehabilitative practice as addressing impairment, activity, and participation-level changes after TBI.
View Article and Find Full Text PDFA comparison of walking performance between individuals with and without asymptomatic peripheral artery disease using the six-minute walk test and the incremental shuttle walk test.
Sci Prog
December 2024
Neuro-Musculoskeletal, Chronic Disease, and Aging Research Engagement Center (I-CARE center), Department of Physical Therapy, Faculty of Associated Medical Sciences, Chiang Mai University, Chiang Mai, Thailand.
Objective: Two walking tests including the six-minute walk test (6MWT) and the incremental shuttle walk test (ISWT) are widely used to evaluate functional ability in individuals with disease conditions. However, it remains unclear whether these walking tests effectively manifest clinical impairment in individuals with asymptomatic peripheral artery disease (PAD). We aimed (i) to compare the walking performance of individuals with and without asymptomatic PAD using the 6MWT and ISWT, and (ii) to investigate the correlation between ankle-brachial index and toe-brachial index (ABI-TBI) and the walking distance.
View Article and Find Full Text PDFCanadian computed tomography head rule and New Orleans criteria in mild traumatic brain injury: Comparison at an urban tertiary care facility in Pakistan.
Surg Neurol Int
November 2024
Department of Neurosurgery, Jinnah Postgraduate Medical Centre, Karachi, Sindh, Pakistan.
Background: Traumatic brain injury (TBI) is a leading cause of mortality and morbidity worldwide, with road traffic accidents being the predominant cause in Pakistan. Computed tomography (CT) scans have become the cornerstone of investigation for all TBIs, but their widespread use raises concerns about cost-effectiveness, radiation exposure, and incidental findings. This study aimed to validate the applicability of the Canadian CT head rule (CCHR) and New Orleans Criteria (NOC) in the Pakistani population and compare their sensitivity and specificity.
View Article and Find Full Text PDFPEGylated Multimeric RNA Nanoparticles for siRNA Delivery in Traumatic Brain Injury.
Small
November 2024
Department of Bioengineering, University of California San Diego, La Jolla, CA, 92093, USA.
Traumatic brain injury (TBI) impacts millions of people globally, however currently there are no approved therapeutics that address long-term brain health. In order to create a technology that is relevant for siRNA delivery in TBI after systemic administration, sub-100 nm nanoparticles with rolling circle transcription (RCT) are synthesized and isolated in order improve payload delivery into the injured brain. Unlike conventional RCT-based RNA particles, in this method, sub-100 nm RNA nanoparticles (RNPs) are isolated.
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