AI Article Synopsis
- Human white adipocytes need a constant supply of precursor cells for fat tissue maintenance, with bone marrow-derived progenitor cells potentially playing a role in this process.
- In a study involving 65 participants who underwent stem cell transplantation, it was found that about 10% of subcutaneous adipocytes come from these bone marrow or peripheral blood stem cell-derived progenitor cells.
- The contribution of these donor cells is notably higher in obese individuals, and genomic analyses indicate that they participate in forming adipose tissue through both differentiation and cell fusion.
Article Abstract
Because human white adipocytes display a high turnover throughout adulthood, a continuous supply of precursor cells is required to maintain adipogenesis. Bone marrow (BM)-derived progenitor cells may contribute to mammalian adipogenesis; however, results in animal models are conflicting. Here we demonstrate in 65 subjects who underwent allogeneic BM or peripheral blood stem cell (PBSC) transplantation that, over the entire lifespan, BM/PBSC-derived progenitor cells contribute ∼10% to the subcutaneous adipocyte population. While this is independent of gender, age, and different transplantation-related parameters, body fat mass exerts a strong influence, with up to 2.5-fold increased donor cell contribution in obese individuals. Exome and whole-genome sequencing of single adipocytes suggests that BM/PBSC-derived progenitors contribute to adipose tissue via both differentiation and cell fusion. Thus, at least in the setting of transplantation, BM serves as a reservoir for adipocyte progenitors, particularly in obese subjects.
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| http://dx.doi.org/10.1016/j.cmet.2015.06.011 | DOI Listing |
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