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Non-genetic risk factors for keratoconus and its progression.
Clin Exp Optom
January 2025
Department of Ophthalmology, University of Auckland, Auckland, New Zealand.
Keratoconus is a multifaceted corneal ectatic disorder characterized by a range of genetic and environmental risk factors. While genetic predisposition significantly influences global disease prevalence rates as well as severity and progression rates, emerging evidence highlights the critical interplay between environmental factors and genetic susceptibility. This article provides a comprehensive overview of environmental risk factors implicated in the onset and progression of keratoconus.
View Article and Find Full Text PDFEnhancing corneal ectasia susceptibility detection: analysis of a new algorithm (BAD-D v4).
Sci Rep
December 2024
Ophthalmology Department, Federal Univeristy of São Paulo, São Paulo, Brazil.
Accurate detection of post-refractive ectasia susceptibility is essential during preoperative evaluation for laser vision correction (LVC) due to the risk of progressive corneal ectasia and vision decline post-surgery. Despite improved screening and a reduced incidence from 0.66 to 0.
View Article and Find Full Text PDFIntrinsic GATA4 expression sensitizes the aortic root to dilation in a Loeys-Dietz syndrome mouse model.
Nat Cardiovasc Res
December 2024
McKusick-Nathans Department of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Loeys-Dietz syndrome (LDS) is a connective tissue disorder caused by mutations that decrease transforming growth factor-β signaling. LDS-causing mutations increase the risk of aneurysm throughout the arterial tree, yet the aortic root is a site of heightened susceptibility. Here we investigate the heterogeneity of vascular smooth muscle cells (VSMCs) in the aorta of Tgfbr1 LDS mice by single-cell transcriptomics to identify molecular determinants of this vulnerability.
View Article and Find Full Text PDFIMPACTS OF POSTERIOR STAPHYLOMA ON PARAPAPILLARY MICROVASCULATURE AND ATROPHY IN HIGH MYOPIC EYES: A Matched Cohort Study With Optical Coherence Tomography Angiography.
Retina
January 2025
Tianjin Key Laboratory of Retinal Functions and Diseases, Tianjin Branch of National Clinical Research Center for Ocular Disease, Eye Institute and School of Optometry, Tianjin Medical University Eye Hospital, Tianjin, China.
Purpose: To evaluate the impacts of the different types of posterior staphyloma (PS) in high myopia on parapapillary microvasculature and parapapillary atrophy (PPA, i.e., γ-zone and δ-zone) with optical coherence tomography angiography.
View Article and Find Full Text PDFCorneal Biomechanical Changes in Patients with Inherited Retinal Diseases.
Clin Ophthalmol
September 2024
Department of Ophthalmology, Centro Hospitalar Universitário de Santo António, Unidade Local de Saúde de Santo António, Porto, Portugal.
Article Synopsis
- Inherited retinal diseases (IRDs) can lead to vision loss and may also affect the eye’s front segment; this study investigates how these conditions relate to corneal health and biomechanics.
- The research involved 154 eyes from 77 IRD patients compared to the same number from healthy controls, assessing measurements like corneal thickness and stiffness.
- Results indicated that IRD patients have softer corneas, increasing their risk for conditions like corneal ectasia and glaucoma, suggesting that corneal evaluations could help in identifying other causes of vision loss in these patients.
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