Objective: Acupuncture at ST36 can produce anti-inflammatory effects, which might be associated with vagus nerve activity. This study explored the effects of electroacupuncture (EA) at ST36 on severe thermal injury-induced remote acute lung injury in rats.
Interventions: Forty male Sprague-Dawley (SD) rats were randomly divided into five groups: (1) the sham (S) group, (2) the thermal injury (TEM) group subjected to 30% total body surface area (30% TBSA) third-degree scald, (3) the EA at ST36 group subjected to EA stimulation at ST36 (3V, 2ms, and 3Hz) after 30% TBSA scald, (4) the EA at non-acupoint group subjected to EA stimulation at non-acupoint after 30% TBSA scald, and (5) the α-bungarotoxin (α7 nicotinic acetylcholine receptor subunit antagonist) group administered 1.0 μg kg(-1) α-bungarotoxin before EA at ST36.
Measurements And Main Results: Thermal injury of 30% TBSA induced leukocytosis in the alveolar space, interstitial edema, and the pro-inflammatory cytokines interleukin (IL)-1β, IL-6, and high-mobility group box 1 (HMGB-1); the expression of both HMGB-1 messenger RNA (mRNA) and protein in lung tissue was significantly enhanced. EA at ST36 significantly downregulated the levels of inflammatory cytokines and improved lung tissue injury. However, pretreatment with α-bungarotoxin reversed the effects of electrical stimulation of ST36.
Conclusions: EA at ST36 might have a potential protective effect on severe thermal injury-induced remote acute lung injury via limitation of inflammatory responses in rats.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.burns.2015.03.004 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Serum lactate and base deficit as prognostic markers in acute burns patients.
Ann Burns Fire Disasters
December 2024
Department of Bioengineering, VIT, Bhopal, India.
Resuscitation of burns remains a fundamental problem in burn care. Traditional endpoints such as mean arterial pressure and urine output guide fluid therapy for optimal resuscitation, but an ideal marker remains controversial. Base deficit and serum lactate are markers of global tissue acidosis and inadequate oxygenation.
View Article and Find Full Text PDFDSM-5 acute stress disorder in hospitalized burn patients: The impact and interplay of pre- and peri-trauma psychological risk factors.
Burns
December 2024
Graduate Institute of Behavioral Sciences, Chang Gung University, Taoyuan, Taiwan; Department of Psychiatry, Chang Gung Memorial Hospital, Linkou, Taoyuan, Taiwan. Electronic address:
Objective: Burn injuries can be traumatic and lead to psychological sequelae, particularly acute stress disorder (ASD). Information regarding the prevalence and risk factors of ASD following DSM-5 criteria is relatively limited among survivors of burn and other traumas. This study aimed to investigate the prevalence of probable ASD post-burn according to DSM-5 criteria and explore the impact and interplay of pre- and peri-trauma psychological risk factors on DSM-5 ASD symptomatology.
View Article and Find Full Text PDFExamining the role of post-traumatic stress disorder, chronic pain and opioid use in burn patients: A multi-cohort analysis.
Scars Burn Heal
December 2024
Department of Family Medicine, University of Texas Medical Branch John Sealy Hospital, Galveston, Texas, USA.
Article Synopsis
- - This study investigates the relationship between Post-Traumatic Stress Disorder (PTSD) and various outcomes like opioid use and chronic pain in burn patients, highlighting that those with PTSD generally face more complications after their injuries.
- - A comprehensive analysis using the TriNetX database compared burn patients with PTSD to those without, factoring in demographic and injury severity differences to assess outcomes across different severity levels.
- - Results showed a higher rate of opioid use and other adverse outcomes in burn patients with PTSD, with the incidence of PTSD varying based on the extent of burns, indicating a clear link between PTSD and poorer recovery experiences.
Identification and quantification of physical activity in critically ill burn patients: A feasibility study.
Burns
November 2024
Alliance of Dutch Burn Centers, Burn Center Martini Hospital Groningen, Groningen, the Netherlands; Hanze University of Applied Sciences Groningen, Research Group Healthy Ageing, Allied Healthcare and Nursing, Groningen, the Netherlands; University of Groningen, University Medical Center Groningen, Department of Human Movement Sciences, Groningen, the Netherlands. Electronic address:
Article Synopsis
- - This study explored using a dual accelerometer method to track physical activity in critically ill burn patients, aiming to gather detailed data on the type and duration of their activities during hospitalization.
- - Conducted in a burn center in the Netherlands, five patients with significant burn injuries participated and wore accelerometers on their chest and thigh to monitor activity, resulting in analysis of 14-49 days of data per patient.
- - The findings showed that while the method effectively identified and quantified activities during wear time, the data processing was labor-intensive and needed improvement for practical clinical use.
[Comparative study of the effect of different doses of human umbilical cord mesenchymal stem cells exosomes on intestinal barrier injury in severely burned rats].
Zhonghua Yi Xue Za Zhi
December 2024
Basic Medical College, Hebei North University, Zhangjiakou075031, China Department of Nutrition, the Fourth Medical Center, Chinese PLA General Hospital, Beijing100037, China.
To explore the therapeutic efficacies of three different doses of human umbilical cord mesenchymal stem cell exosomes (hucMSC-EXO) on the injury of intestinal barrier structure and dysfunction in severely burned rats, and to identify the optimal dose of hucMSC-EXO for the repair of intestinal barrier injury. The hucMSC-EXO was isolated and identified by using an exosome extraction and purification kit. A total of 30 specific pathogen free (SPF) male Wistar rats (aged 6-8 weeks) were selected, and were randomly divided into five groups (=6) using a random number table: sham group, burn group, burn+100 μg hucMSC-EXO group (Burn+EXO100), burn+200 μg hucMSC-EXO group (Burn+EXO200), and burn+400 μg hucMSC-EXO group (Burn+EXO400).
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!