AI Article Synopsis
- GPR64/ADGRG2 is crucial for male fertility, and its disruption can lead to infertility, making it a potential target for fertility control.
- GPR64 is classified as an orphan receptor, meaning its natural activating substance and signaling pathway are unknown.
- This study discovered that GPR64 can be activated by synthetic peptides from its Stachel sequence, allowing for potential external manipulation of the receptor's activity for research or therapeutic purposes.
Article Abstract
The epididymis-specific adhesion G protein-coupled receptor (aGPCR) GPR64/ADGRG2 has been shown to be a key-player in the male reproductive system. As its disruption leads to infertility, GPR64 has drawn attention as potential target for male fertility control or improvement. Like the majority of aGPCRs GPR64 is an orphan receptor regarding its endogenous agonist and signal transduction. In this study we examined the G protein-coupling abilities of GPR64 and showed that it is activated through a tethered agonist sequence, which we have previously identified as the Stachel sequence. Synthetic peptides derived from the Stachel region can activate the receptor, opening for the first time the possibility to externally manipulate the receptor activity.
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| http://dx.doi.org/10.1016/j.bbrc.2015.07.020 | DOI Listing |
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