AI Article Synopsis
- Primary squamous cell carcinoma is extremely rare, making up only 0.04-0.07% of gastric cancer cases.
- An 81-year-old man received chemoradiotherapy for gastric cancer, resulting in the disappearance of the tumor after a year, but a white area of tissue later appeared, which was initially normal.
- Five years later, an elevated lesion in the same area was biopsied and found to be squamous cell carcinoma, which was treated through endoscopic submucosal dissection, suggesting the cancer may have developed from changes in the tissue due to previous radiation therapy.
Article Abstract
Primary squamous cell carcinoma is rarely observed, with a reported incidence of 0.04-0.07 % of all gastric cancers. An 81-year-old male underwent chemoradiotherapy for type 1 gastric cancer of the posterior wall of the cardiac region in 2005. The tumor disappeared after 1 year of therapy, following which an area of white epithelium, approximately 30 mm in diameter and continuous with the esophageal mucosa, became visible. Biopsy of the white epithelium indicated normal squamous epithelium. An elevated lesion was subsequently detected in the area of white epithelium on upper gastrointestinal endoscopy during a follow-up examination 5 years after therapy. As a biopsy of the same site indicated squamous cell carcinoma, we performed endoscopic submucosal dissection. Histopathological examination indicated high-grade fibrosis due to radiotherapy and showed a moderately differentiated squamous cell carcinoma invading the scarred portion. We describe a case where the developmental process of a squamous cell carcinoma was observed using endoscopy, including narrow band imaging with magnification. This carcinoma likely originated from squamous metaplasia that developed after chemoradiotherapy was administered for a gastric cancer.
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| http://dx.doi.org/10.1007/s12328-014-0503-5 | DOI Listing |
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