AI Article Synopsis
- Myocardial infarction (MI) animal studies help researchers understand disease mechanisms and explore new treatments, particularly through experiments using NOD/Scid mice.
- In the study, permanent ischemia (PI) MI caused more severe cardiac damage compared to transient ischemia (IR), indicating PI models are better suited for investigating cell therapies despite IR being more representative of clinical practice.
- Both types of MI led to significant inflammatory changes in the mice, highlighting the value of this mouse strain for studying human cell therapy applications.
Article Abstract
Myocardial infarction animal studies are used to study disease mechanisms and new treatment options. Typically, myocardial infarction (MI) is induced by permanent occlusion of the left anterior descending artery. Since in MI patients coronary blood flow is often restored new experimental models better reflecting clinical practice are needed. Here, permanent ischemia MI (PI group) was compared with transient ischemia (45 min) (IR group) in immunodeficient NOD/Scid mice. Cardiac function, infarct size, wall thickness and total collagen deposition were significantly reduced only in PI mice. Cardiac inflammatory cells and serum cytokine levels were less dynamic in IR animals compared to PI. So although IR better reflects clinical practice, it is secondary to PI for investigating cell therapy, since it induces too little damage to provide a measurable therapeutic window. MI did result in significant changes in the inflammatory state, indicating this immunodeficient mouse strain is valuable to study human cell therapy.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4498004 | PMC |
| http://dx.doi.org/10.1186/s40064-015-1128-y | DOI Listing |
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