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Steroids and steroid-like compounds alter the ion permeability of phospholipid bilayers distinct interactions with lipids and interfacial water.
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School of Chemistry and Molecular Biosciences, University of Queensland, St Lucia QLD 4072, Australia.
Steroids are organic compounds found in all forms of biological life. Besides their structural roles in cell membranes, steroids act as signalling molecules in various physiological processes and are used to treat inflammatory conditions. It has been hypothesised that in addition to their well-characterised genomic and non-genomic pathways, steroids exert their biological or pharmacological activities an indirect, nonreceptor-mediated membrane mechanism caused by steroid-induced changes to the physicochemical properties of cell membranes.
View Article and Find Full Text PDFUnlocking new possibility of FeO@C@Ag nanostructures as an advanced SERS substrate for ultrasensitive detection of low-cross-section urea biomolecules.
RSC Adv
January 2025
Phenikaa University Nano Institute (PHENA), Phenikaa University Hanoi 12116 Vietnam
Surface-enhanced Raman spectroscopy (SERS) is widely recognized as a powerful analytical technique, offering molecular identification by amplifying characteristic vibrational signals, even at the single-molecule level. While SERS has been successfully applied for a wide range of targets including pesticides, dyes, bacteria, and pharmaceuticals, it has struggled with the detection of molecules with inherently low Raman scattering cross-sections. Urea, a key nitrogen-containing biomolecule and the diamide of carbonic acid, is a prime example of such a challenging target.
View Article and Find Full Text PDFResponse and variation mechanisms of RDX crystals under strong magnetic loading.
RSC Adv
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The Second Department, Xi' an Modern Chemistry Research Institute Xi'an 710065 China
To fully understand the variation in performance of cyclotrimethylenetrinitramine (RDX) crystals under strong magnetic field exposure, the strong magnetic loading of RDX was conducted in both stable and alternating magnetic fields. The morphological changes of RDX crystals exposed to magnetic fields were studied under a scanning electron microscope. Then, the lattice changes of RDX exposed to magnetic fields were analyzed through X-ray diffraction and Raman spectroscopy.
View Article and Find Full Text PDFJunctional Role of Anionic Domain of Mussel Foot Protein Type 4 in Underwater Mussel Adhesion.
Biomacromolecules
January 2025
Department of Chemical Engineering, Pohang University of Science and Technology, Pohang 37673, Republic of Korea.
Mussel byssi form a robust underwater adhesive system, anchoring to various surfaces in harsh marine environments. Central to byssus is foot protein type 4 (fp-4), a junction protein connecting collagenous threads to proteinaceous plaque. This study investigated an anionic plaque-binding domain of fp-4 (fp-4a) and its interactions with cationic foot proteins (fp-1, fp-5, and fp-151 as model substitutes for fp-2) and metal ions (Ca, Fe, and V).
View Article and Find Full Text PDFInsight into the effect of ZIF-8 on the interaction between drugs and protein/cell.
Int J Biol Macromol
January 2025
School of Pharmaceutical Sciences, Liaoning University, Shenyang 110036, China. Electronic address:
Understanding the impact of nanomaterials on drug-protein/cell interactions is crucial for comprehending their in vivo biological effects. We investigated the impact of zeolitic imidazolate framework (ZIF)-8 on the interaction between curcumin (Cur) and human serum albumin (HSA) using various spectroscopic techniques and molecular docking. Additionally, we examined its effect on drug-cell interaction using HepG2 cells and Escherichia coli (E.
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