AI Article Synopsis
- The study focuses on creating and testing various derivatives of salicylic acid for their ability to scavenge free radicals, using the DPPH method.
- Gentisic acid and its modified forms (esters, amides, and amino versions) show greater radical scavenging ability compared to regular salicylic acid and other similar compounds.
- This enhanced radical scavenging capacity may open new avenues for developing anti-inflammatory drugs by utilizing mechanisms like single electron or hydrogen atom transfer.
Article Abstract
The synthesis and antioxidant evaluation by DPPH scavenging of a series of salicylic acid derivatives is described. Gentisic acid and its ester, amide, and amino analogs possess more radical scavenging capacity than salicylic acid and other salicylate derivatives. This property can possibly provide an additional pathway for anti-inflammatory activity through either single electron or hydrogen atom transfer, leading to a new strategy for the design of anti-inflammatory agents.
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| http://dx.doi.org/10.1016/j.bmcl.2015.07.001 | DOI Listing |
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