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The Origin(s) of LUCA: Computer Simulation of a New Theory.
Life (Basel)
January 2025
Center for Complex Decision Analysis, Fudan University, Shanghai 200433, China.
Carl Woese's thesis of cellular evolution emphasized that the last universal common/cellular ancestor (LUCA) must have evolved by drawing from "global inventions". Yet, existing theories regarding the origin(s) of LUCA have mostly centered upon scenarios that LUCA had evolved mostly independently. In an earlier paper, we advanced a new theory regarding the origin(s) of LUCA that extends Woese's original insights.
View Article and Find Full Text PDFMoral Complexity in Traffic: Advancing the ADC Model for Automated Driving Systems.
Sci Eng Ethics
January 2025
Department of Philosophy and Religious Studies, North Carolina State University, Raleigh, NC, USA.
The incorporation of ethical settings in Automated Driving Systems (ADSs) has been extensively discussed in recent years with the goal of enhancing potential stakeholders' trust in the new technology. However, a comprehensive ethical framework for ADS decision-making, capable of merging multiple ethical considerations and investigating their consistency is currently missing. This paper addresses this gap by providing a taxonomy of ADS decision-making based on the Agent-Deed-Consequences (ADC) model of moral judgment.
View Article and Find Full Text PDFDesign, Synthesis, and Biological Evaluation of Thieno[3,2-]pyrimidine Derivatives as the First Bifunctional PI3Kδ Isoform Selective/Bromodomain and Extra-Terminal Inhibitors.
J Med Chem
January 2025
College of Pharmacy, National & Local Joint Engineering Research Center of Targeted and Innovative Therapeutics, IATTI, Chongqing University of Arts and Sciences, Chongqing 402160, China.
The concomitant inhibition of PI3Kδ and bromodomain and extra-terminal (BET) that exerts a synergistic effect on the B-cell receptor signaling pathway provides a new strategy for the treatment of aggressive diffuse large B-cell lymphoma (DLBCL). Herein, a merged pharmacophore strategy was utilized to discover a series of thieno[3,2-]pyrimidine derivatives as the first-in-class bifunctional PI3Kδ-BET inhibitors. Through optimization, a highly potent compound () was identified to possess excellent and balanced activities against PI3Kδ [inhibitory concentration (IC) = 112 ± 8 nM] and BRD4-BD1 (IC = 19 ± 1 nM) and exhibited strong antiproliferative activities in DLBCL cells.
View Article and Find Full Text PDFBiodiversity at risk in the SPAMI Pelagos Sanctuary: The impact of marine litter on biota.
Sci Total Environ
January 2025
Department of Physical, Earth and Environmental Sciences, University of Siena, Italy; NBFC, National Biodiversity Future Center, Palermo, Italy.
The Mediterranean basin is the second largest global biodiversity hotspot in the world, which coexists with a plethora of anthropogenic stress. This study examines the risks that marine litter poses to Mediterranean biodiversity, using the Special Protection Area of Mediterranean Importance (SPAMI) "Pelagos Sanctuary" as a case study. In this paper, a new survey method and data analysis strategies to assess the impact of marine litter, including microplastics, on Mediterranean organisms, is proposed.
View Article and Find Full Text PDFRefining Established Practices for Research Question Definition to Foster Interdisciplinary Research Skills in a Digital Age: Consensus Study With Nominal Group Technique.
JMIR Med Educ
January 2025
Digital Society Initiative, University of Zurich, Zurich, Switzerland.
Background: The increased use of digital data in health research demands interdisciplinary collaborations to address its methodological complexities and challenges. This often entails merging the linear deductive approach of health research with the explorative iterative approach of data science. However, there is a lack of structured teaching courses and guidance on how to effectively and constructively bridge different disciplines and research approaches.
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