AI Article Synopsis
- * A case study details a child with CNS medulloepithelioma who underwent high-dose chemotherapy followed by autologous stem cell transplantation, avoiding radiotherapy altogether.
- * Remarkably, three years after treatment, the patient showed no signs of relapse and achieved normal developmental progress, marking a significant milestone as the first known instance of long-term survival using this treatment approach for this type of tumor.
Article Abstract
Medulloepithelioma of the central nervous system (CNS) is a rare primitive neuroectodermal tumor characterized by highly malignant behavior occurring in early childhood. Few cases have been reported and optimal management remains unknown. Here, we report a case of CNS medulloepithelioma successfully treated with high-dose chemotherapy (HDCTX) followed by autologous stem cell transplantation (auto-SCT) without radiotherapy. At the last follow-up, 3.0 years after onset, the patient was alive with no sign of relapse and normal development. To the best of our knowledge, this is the first reported case of long-term survival of CNS medulloepithelioma treated by HDCTX/auto-PBSCT without radiotherapy.
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| http://dx.doi.org/10.1097/MPH.0000000000000381 | DOI Listing |
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