Paradoxical worsening of tuberculous chorioretinitis in a Chinese gentleman.

J Ophthalmic Inflamm Infect

Department of Ophthalmology, Tan Tock Seng Hospital, Singapore, 308433 Singapore.

Published: July 2015

We report a case of paradoxical worsening of tuberculous chorioretinitis after initiation of anti-tuberculous therapy (ATT). The patient had left panuveitis with tuberculous chorioretinitis and was started on systemic ATT and oral steroids a week later. However, he developed paradoxical worsening 2 months after initiation of therapy. He was continued on ATT, oral steroids and intravitreal amikacin with resolution of the chorioretinal lesion subsequently. Ocular tuberculosis often poses a diagnostic challenge, and clinicians should be aware of the possibility of paradoxical worsening despite appropriate ATT. Clinicians should strongly consider starting oral steroids concurrently with ATT when managing ocular tuberculosis.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4496418PMC
http://dx.doi.org/10.1186/s12348-015-0052-1DOI Listing

Publication Analysis

Top Keywords

paradoxical worsening
16
tuberculous chorioretinitis
12
oral steroids
12
worsening tuberculous
8
att oral
8
ocular tuberculosis
8
att
5
paradoxical
4
chorioretinitis chinese
4
chinese gentleman
4

Similar Publications

is a common pathogen that causes foodborne illness worldwide. There is limited evidence describing the treatment of gastrointestinal non-typhoidal (NTS). Clinicians are inclined to treat these infections with antibiotics, but the use of antibiotics may paradoxically worsen gastrointestinal symptoms and prolong bacterial stool shedding.

View Article and Find Full Text PDF

High sugar intake, particularly fructose, is implicated in obesity and metabolic complications. On the other hand, fructose from fruits and vegetables has undisputed benefits for metabolic health. This raises a paradoxical question-how the same fructose molecule can be associated with detrimental health effects in some studies and beneficial in others.

View Article and Find Full Text PDF

Background: Aneurysmal subarachnoid hemorrhage (aSAH) is often associated with acute high-pressure hydrocephalus. Less commonly, an acute low-pressure hydrocephalus (ALPH) variant can develop and contribute to increased morbidity. ALPH is particularly challenging to diagnose and manage, as patients present with symptoms of increased intracranial pressure (ICP) despite the absence of corroborating evidence from ICP measurements.

View Article and Find Full Text PDF

Breast cancer treatment delay and the Hispanic paradox: A SEER database analysis.

Am J Surg

December 2024

Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA; Division of Hematology and Oncology, Tufts Medical Center, Boston, MA, USA.

Background: Breast cancer (BC) is the most common cancer in US women. Knowledge gaps exist regarding healthcare inequities in Hispanic BC patients. This study assessed BC characteristics and treatment patterns among Hispanics.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!